Anti-metastatic activity

Taraboletti G, Gatto C, Riva A, et al. Anti-Angiogenic and Anti-Metastatic Activity of IDN 5390, a New C-Seco Taxane Derivative. Proceedings of the AACR, Vol. 42, March 2001. abstract 3162. 

Pavco, P.A., Bouhana, K.S., Gallegos, A.M., Agrawal, A., Blanchard, K.S., Grimm, S.L. et al. (2000) Anticancer and anti-metastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin. Cancer Res., 6, 2094-2103. 

Milk fat contains small amounts of ether lipids. Synthetic ether lipids at low concentrations are potent anti-neoplastic agents. Cell culture studies showed that they inhibited cell growth, induced differentiation, promoted apoptosis and showed anti-metastatic activity. In human chemoprevention trials ether lipids have been administered parenterally. Although the ether bond is preserved when these lipids are delivered orally, no cancer chemoprevention studies have utilized dietary ether lipids (Parodi, 2004). 

Barratt, G. Puisieux, F. Yu, W.P. Foucher, C. Fessi, H. Devissaguet, J.P. Anti-metastatic activity of MDP-L-alanyl-cholesterol incorporated into various types of nanocapsules. Int. J. Immunopharmacol. 1994, 16, 457-461. 

Mannostatin A, a pentasubsthuted amino-cyclopentane produced by Streptoverticillium verticillus var quintum ME3-AG3 [113], is also a specific inhibitor of a-D-mannosidase and has shown anti-metastatic activity [114],... 

Menon, L.G., Kuttan, R., and Kuttan, G., Anti-metastatic activity of curcumin and catechin. Cancer Lett., 141 (1-2), 159-165, 1999. 

Akiyama, T. (2000). Wnt/p-catenin signaling. Cytokine Growth Factor Rev. 11, 273-282. Alekseyenko, T. V., Zhanayeva, S. Y., Venediktova, A. A., Zvyagintseva, T. N., Kuznetsova, T. A., Besednova, N. N., and Korolenko, T. A. (2007). Antitumor and anti-metastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga. Bull. Exp. Biol. Med. 143(6), 730-732. 

Karuppaiya, P., Satheeshkumar, E., Chao, W.T., Kao, L.Y., Chen, E.C., Tsay, H.S., 2013. Anti-metastatic activity of biologically synthesized gold nanoparticles on hiunan fibrosarcoma cell line HT-1080. Colloids Surf. B Biointerfaces 110, 163—170. 

Weng CJ, Yen GC (2012) Havonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev 31 323-351... 

Fazioli F., Blasi F. Urokinase-type plasminogen activator and its receptor New target for anti-metastatic therapy Trends Pharmacol Sci 1994 15,25-9. 

Anti-tumor activity of bevacizumab has been reported in various preclinical animal models (primary and metastatic) with a broad array of tumor types [106, 107]. Clinical studies have further validated the focal role of VEGF in cancer. A single infusion of bevacizumab at 5 mg/kg in patients with primary and locally advanced adenocarcinoma of the rectum demonstrated direct and rapid antivascular effect in human tumors, with decreases in tumor perfusion, vascular volume, microvascular density, and interstitial pressure [108]. Clinical efficacy of bevacizumab in combination with 5-FU- and irinotecan-based regimens has been demonstrated in patients with metastatic colorectal cancer a significant improvement in overall survival time was observed compared with chemotherapy alone (20.3 versus 15.6 months for chemotherapy plus bevacizumab versus chemotherapy alone) [109]. 

The naturally occurring PP2A inhibitor cytostatin (152), which was isolated from a Streptomyces inhibits the adhesion of B16 melanoma cells to laminin and collagen, displays anti metastatic and cytotoxic activity and induces apoptosis of B16 melanoma cells. The synthesis of the 4S,5S,6S,10S,11S,12S isomer of cyto-... 

Rini B, Rixe O, Bukowski R, et al. (2005) AG-013736, a multitarget tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC). ASCO Proc (abstract 4509). 

Celosia argentea L. -suspiro Tranquilizer No information Quilombolas [48] Betalains [84,85] Anti-diabetic activity [248] anti-metastatic and immunomodulating properties [249] immunostimulating activity [250] hepatoprotective effects [251]... 

The peptide CXCR4 antagonist TN14003 has demonstrated antitumor efficacy in two animal models of metastatic breast and head and neck cancer [48, 103]. Animals were treated with the CXCR4 peptide by intraperitoneal injection for 35 days. Tumors at the primary subcutaneous site of injection as well as the number of lung metastasis were inhibited. In the head and neck animal model, antitumor activity was correlated with anti-angiogenic activity of the anti-CXCR4 treatment. 

YC-1,3-(5 -hydroxymethyl-2 -furyl)-l-benzylindazole, a soluble guanylyl cyclase stimulator, has been shown in several xenograft cancer models to inhibit HIF-la protein expression and to have anti-angiogenic activity [212]. In addition, in an animal model of metastasis, YC-1 treatment dramatically reduced cell migration and metastatic burden [213]. Likewise, YC-1 treatment has been shown to decrease bone metastases derived from MDA-MD-231 breast cancer cells that were introduced into animals by intracardiac injection [214]. YC-1 was recently reported in a human lung cancer cell line to also reduce cell proliferation to block activation of matrix metalloproteinases (MMP-2 and MMP-9) and to reduce cyclin D1 expression [215]. However, to date no clinical trials using YC-1 have been initiated. 

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