Anti-diabetic activity

Sabu, M.C. Ramadasan, K (2002). Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. Journal of Ethnopharmacology, Vol. 81, No.2, (July 2002), pp. 155-160, ISSN 0378-8741. 

Diabetic patients have reduced antioxidant defences and suffer from an increased risk of free radical-mediated diseases such as coronary heart disease. EC has a pronounced insulin-like effect on erythrocyte membrane-bound acetylcholinesterase in type II diabetic patients (Rizvi and Zaid, 2001). Tea polyphenols were shown to possess anti-diabetic activity and to be effective both in the prevention and treatment of diabetes (Choi et al, 1998 Yang et al, 1999). The main mechanism by which tea polyphenols appear to lower serum glucose levels is via the inhibition of the activity of the starch digesting enzyme, amylase. Tea inhibits both salivary and intestinal amylase, so that starch is broken down more slowly and the rise in serum glucose is thus reduced. In addition, tea may affect the intestinal absorption of glucose. 

HV033 Park, ], H., B. K. Kim, M. K. Park, et al. Anti-diabetic activity of herbal drugs. Korean J Pharmacog 1997 ... 

The chiroptieal properties of the benzodioxole 26 have been examined <03OBC391> and the photochromism of compound 27 has been studied <03ARK(xiii)147>. Anti-diabetic activity is claimed for compound 28 <03WOP2550> and the spiro indolone/dioxolanes 29 have monoamine oxidase inhibiting and psychostimulant properties <01RRC517>. 

Celosia argentea L. -suspiro Tranquilizer No information Quilombolas [48] Betalains [84,85] Anti-diabetic activity [248] anti-metastatic and immunomodulating properties [249] immunostimulating activity [250] hepatoprotective effects [251]... 

The frait pods are regarded as a digestive, carminative, laxative, expectorant and blood tonic (Komutarin et al., 2004, cited in 16)). Other parts of the plant present antioxidant (Tsuda et al, 1994, cited in 16)), anti-hepatoxic (Joyeux et al, 1995, cited in 16)), anti-inflammatory (Rimbau et al., 1999, cited in 16)), anti-mutagenic (Ramos et al., 2003, cited in 16)), and anti-diabetic activities (Maiti et al, 2004, cited in 16)). 

Kubo, K., Aoki, H., and Nanba, H., Anti-diabetic activity in the ITuit body of Grifola frondosa (Maitake), Bio/. Pharm. Bull, 17,1106-1110,1994. 

Pepato, M.T., E.H. Keller, A.M. Baviera, et al. 2002. Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-dia-betic rats. /. Ethnopharmacol. 81(2) 191-197. 

Ravi, K., K. Sivagnanam, and S. Subramanian. 2004. Anti-diabetic activity of Eugenia jambolana seed kernels on streptozotocin-induced diabetic rats. /. Med. Food 7(2) 187-191. 

Kumar, G.P.S., P. Arulselvan, D.S. Kumar, and S.P. Subramanian. 2006. Anti-diabetic activity of fruits of Terminalia chebula on streptozotocininduced diabetic rats. /. Health Sci. 52(3) 283-291. 

The anti-diabetic drug phenformin (jS-phenylethylbiguanide) forms chelates with cupric ions with avidity similar to that of glycine. Among related compounds, the ability to chelate copper runs parallel to the anti-diabetic activity which is effected by inhibition of hepatic gluconeogenesis (Foye, O Laughlin and Duvall, 1961). 

Vetrichelvan, T, Jegadeesan, M., Devi, B.A. Anti-diabetic activity of alcoholic extract of Celosia argentea LINN. Seeds in rats. Bio. Pharm. Bull. 25(4), 526-528 (2002)... 

Table 7.6 Natural extracts with no described antidiabetic activity (but from the same germs as plants with extracts with described anti-diabetic activity) that contain molecules that are predicted...

Tank, R., Sharma, N., Sharma, L, and Dixit, V.P. 1990. Anti-diabetic activity of Curcuma longa (ethanol extract) in alloxan induced diabetic rats. Indian Drugs, 27 587-589. 

Kiho, T., Morimoto, H., Sakushima, M., Usui, S., and Ukai, S. 1995. Polysaccharides in fungi. XXXV. Anti diabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella aurantia. Biological and pharmaceutical bulletin, 18(12), 1627-9. 

Kim, Y.W., Kim, K.H., Choi, H.J., and Lee, D.S. 2005. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnology letters, 27(1), 483-7. 

Extensive profiling needs to be done for M. pudica which will elucidate the compounds showing particular activities like anti-diabetic activity. Various literatures clearly support anti-diabetic and diabetes related complications along with various others stated above. The use of major bioactives from M. pudica on the lowering of diabetic markers was found to be exploitable based on the literatures reviewed below in course of this discussion. The plant was found to be able to work as anti-diabetic, hypolipidemic, wound healer, anti-oxidant and free radical scavenger among other uses of this plant (see Table 3). 

N.G. Sutar, U N. Sutar, B.C. Behera, Anti-diabetic activity of Mimosa pudica Linn. On albino rats, J. Herbal Medicine and Toxicol. 3 (2009) 123-126. 

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