Anti-inflammatory/analgesic agents

Goudie, A. C., Rosenberg, H. E., Ward, R. W. 4,5,8,9-Tetrahydro-8-methyl-9-oxothieno[3, 2 5,6]cyclohepta[1,2-b]pyrrole-7-acetic acid. A new anti-inflammatory/analgesic agent. J. Heterocycl. Chem. 1983, 20,1027-1030. 

From a series of 5,6-diphenylpyridazines prepared in Italy [91], chloro derivatives of type (20, R = 4-Me2NC6H4, 4-MeOC6H4) have been found to be anti-inflammatory, analgesic and antipyretic agents superior to phenylbutazone when tested in mice or rats. 

Beta-blockers interact with a large number of other medications. The combination of beta-blockers with calcium antagonists should be avoided, given the risk for hypotension and cardiac arrhythmias. Cimetidine, hydralazine, and alcohol all increase blood levels of beta-blockers, whereas rifampicin decreases their concentrations. Beta-blockers may increase blood levels of phenothiazines and other neuroleptics, clonidine, phen-ytoin, anesthetics, lidocaine, epinephrine, monoamine oxidase inhibitors and other antidepressants, benzodiazepines, and thyroxine. Beta-blockers decrease the effects of insulin and oral hypoglycemic agents. Smoking, oral contraceptives, carbamazepine, and nonsteroidal anti-inflammatory analgesics decrease the effects of beta-blockers (Coffey, 1990). 

Thiazolyl and benzothiazolyl derivatives are known for their anti-inflammatory, analgesic, and antipyretic activities [72-77], for example Meloxicam (Fig. 3) is a known non-steroidal anti-inflammatory agent with a thiazolyl... 

Hamdy M, Rahman A, Hussein M (2006) Synthesis of / -hydroxypropanoic acid derivatives as potential anti-inflammatory, analgesic and antimicrobial agents. Arch Pharm Chem Life Sci 339 378-387... 

Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are well known and have been widely used to treat various ailments for over 100 years. As a class, these agents possess anti-inflammatory, analgesic and anti-pyretic activity and are chiefly used to treat chronic inflammatory states... 

Tolmetin is an anti-inflammatory, analgesic, and antipyretic agent that, in recommended doses (200-600 mg three times a day), appears to be approximately equivalent in efficacy to moderate doses of aspirin. Tolmetin possesses typical tNSAID properties and side effects. 

Apazone is a tNSAID that has anti-inflammatory, analgesic, and antipyretic activity and is a potent uricosuric agent. It is available in Europe but not the U.S. Some of its function may arise from its ability to inhibit neutrophil migration, degranulation, and superoxide production. 

Sherif A. F. R, Ibrahim M. El-A, Heba A. A. Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents, Bioorg. Med. Chem. 2009. p.882 - 895. DOI 10.1016/j.bmc.2008.11.035... 

Analgesics Antiasthamatics Antidepressants Antifungal agents Anti-inflammatories Antianxiety agents Antimigraine agents Hypnotics... 

FIGURE 6 5-Alkynyl-l-beta-D-ribofuranosylimidazole-4-carboxamide 31 known as EICAR with broad-spectrum antiviral agent and pyrimido[l,6-fl]benzimidazole derivative 32 as potent anti-inflammatory-antimicrobial agent with analgesic activity [96]. 

Imidazole, a well-known five-membered heterocyclic compound, is a major source of interest for a variety of medicinal agents. Imidazole derivatives show various pharmacological activities such as antiviral, anti-inflammatory, analgesic, anhdepressant, antifungal, anhbacterial, anticancer, antitubercular, and antileishmanial activities (Figure 6) [94,95]. 

Synonyms Citrus aurantium dulcis wax Orange peel wax Orange wax Definition Wax obtained from the peel of the orange, Citrus aurantium duicis Uses Emollient, moisturizer, UV-A and -B absorber, natural antioxidant, mild antimicrobial, fragrance, dispersant, wetting agent in cosmetics, sun care, makeup, shampoos, pharmaceuticals anti-inflammatory, analgesic (on burns) solubilizer water resist, aid... 

In addition, various pyridopyridazines have been claimed to have activity as antibacterials and antiseptics, antitubercular agents, analgesics, anti-inflammatories, antiallergics, tranquillizers, CNS depressants and muscle relaxants. 

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