Antitubercular agent

Aminosalicylic acid and its salts have been used in the treatment of tuberculosis, Aminosalicylic acid can be prepared by the carboxylation of m- am in oph en o1 (32). Aminosalicylic acid USP assays not less than 98.5% and not more than 100.5%, calculated on the anhydrous basis. The antitubercular agents are likely to be used as the more tolerated salts calcium [133-15-3] potassium [133-09-5] sodium [133-10-8] and the ethyl [6069-17-2] and phenyl [133-11-9] esters of -aminosalicylic acid. 

L-Dopa and Trimethoprim are two other dmgs that can be made from vanillin. u-Dopa is used for the treatment of Parkinson s disease Trimethoprim is an antiinfective agent used mainly for urinary tract infections and certain venereal diseases. Also, Mebeverine, an antispasmodic agent, and Verazide, a generic antitubercular agent, are dmgs that can be made from vanillin or its derivatives. 

In addition, various pyridopyridazines have been claimed to have activity as antibacterials and antiseptics, antitubercular agents, analgesics, anti-inflammatories, antiallergics, tranquillizers, CNS depressants and muscle relaxants. 

Ethambutol (Myambutel) [Antitubercular Agent] Uses Pulm TB other mycobacterial Infxns, MAC Action i RNA synth Dose Adults Feds >12 y. 15-25 mg/kg/d PO single dose X in renal impair, take w/ food, avoid antacids Caution [B, +] Contra Unconscious pts, optic neuritis Disp Tabs SE HA, hyperuricemia, acute gout, abd pain, T LFTs, optic neuritis, GI upset Interactions T Neurotox W/ neurotoxic drugs X effects W/ A1 salts EMS May affect glucose (hypoglycemia) may cause vision problems OD Sxs unknown activated charcoal may be effective symptomatic and supportive... 

Isoniazid (INH) [Antitubercular Agent] Uses Rx prophylaxis of TB Action Bactericidal interferes w/ mycolic acid synth, disrupts cell wall Dose Adults. Active TB 5 mg/kg/24 h PO or IM (usually 300 mg/d) or DOT 15mg/kg... 

Rifapentine (Priftin) [Antibiotic/Antitubercular Agent] Uses Pulm TB Action X DNA-dependent RNA polymerase. Dose Intensive phase ... 

A 32-year-old Haitian man has acute-onset confusion and suicidal ideation. Two weeks ago he began combination therapy for multi-drug resistant pulmonary tuberculosis. He has a history of depression that required intermittent treatment in the past. Which of the following antitubercular agents is responsible for the patient s neurological symptoms ... 

Mechanism of Action An antitubercular agent that inhibits peptide synthesis. Therapeutic Effect Suppresses mycobacterial multiplication. Bactericidal. Pharmacokinetics Rapidly absorbed from the gastrointestinal (Gl) tract. Widely distributed. Protein binding 10%. Metabolized in liver. Primarily excreted in urine. Removed by hemodialysis. Half-life 2-3 hr (half-life is increased with impaired renal function). 

Hydrazides have also been used as nucleophiles for ring opening to give the corresponding bis(acylhydrazides) 540. ° Subsequent cyclodehydration of 540 leads to the 4-alkylidene(arylidene)imidazolones 541 that have been evaluated as anticonvulsant, antihelmintic, antibacterial, antifungal, antiviral, and antitubercular agents (Scheme... 

Reaction of cyanopyrazine and its 6-chloro derivative with hydrazine gives the corresponding amidrazones, these compounds have been prepared for testing as antitubercular agents.262b... 

Reimers D, Jezek A. Rifampicin und andere Antituberkulohka bei gleichzeitiger oraler Kontrazeption. [The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives.] Prax Pneumol 1971 25(5) 255-62. 

Chemical/Pharmaceutical/Other Class Isonicotinic acid derivative Antitubercular agent... 

Spanish Fly cantharides. spantide I [DArg, oTrp -, Leu ] Pl-ll. sparfloxacin [ban. inn. usan] fluoroquinolone, is a broad-spectrum ANTIBACTERIAL which can be used as an ANTILEPROTIC and ANTITUBERCULAR AGENT. 

---