Anti-pyretic activity

According to Ramadan and cowoikers (36), aqueous extract of the baobab fruit pulp produces a marked anti-inflammation activity. The effect was comparable to that induced by standard phenylbutazone (15 mg/kg). This antiinflammatory effect may be due to the presence of sterols, saponins and triterpenes in the aqueous extract. The extract also shows a marked antipyretic activity (36). The antipyretic activity of the extract resembles that normally induced by standard dose of administered acetylsalicyhc acid (ASA) in hyperthermic rats. Leaves are applied locally for a variety of inflammatoiy conditions, insect bites and guinea worm sores (8). Anti-pyretic activity has been reported (36). 

Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin are well known and have been widely used to treat various ailments for over 100 years. As a class, these agents possess anti-inflammatory, analgesic and anti-pyretic activity and are chiefly used to treat chronic inflammatory states... 

Two chalcones (281, 282) and fourteen flavonoids (283-296) were isolated from the hexane extract of the rhizomes of K. parviflora [the plant was previously described as Boesenbergia pandurata (Roxb) Schlr. (black rhizome)] and compound 288 was found to be the major constituent of the extract [267, 268]. Anti-inflammatory and anti-pyretic activities of 288 were determined to be comparable to that of aspirin [269]. Several flavonoids and flavonoid glycosides were isolated from the leaves of K. rotunda, K. pulchra and K. elegans [233]. 

Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature. 1972 240 410-411. 

Indomethacin is a potent anti-inflammatory and anti-pyretic compound. Given orally, it inhibits the formation of the cotton-pellet granuloma in the rat, being about 85 times more potent than phenylbutazone, and equally active in both intact and adrenalectomized rats. It inhibits oedema of the rat-foot, produced by either carrageenan or mustard, but does not inhibit that produced by egg-white, formalin, yeast or 5-hydroxytryptamine. As an antipyretic, it is 10-20 times more powerful than phenylbutazone. Indomethacin is well absorbed in all species, but there is considerable variation in its distribution and metabolism. Man tolerates the drug better than do other species, and is less liable to the gastro-intestinal irritation encountered in experimental animals . ... 

Products and Uses An OTC (over-the-counter) analgesic, anti-inflammatory, anti-pyretic (to reduce fever). Certain foods contain salicylates, the active ingredient in aspirin. They may afford the same benefits. They are raisins, prunes, dates, dried currants, raspberries, blueberries, cherries and Granny Smith apples. 

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