Anti-hypersensitivity agent

The answer is b. (Hardman, p 1077.) Oxacillin is classified as a penicillinase-resistant penicillin that is relatively acid-stable and, therefore, is useful for oral administration. Major adverse reactions include penicillin hypersensitivity and interstitial nephritis. With the exception of methi-cillin, which is 35% bound to serum proteins, all penicillinase-resistant penicillins are highly bound to plasma proteins. Oxacillin has a very narrow spectrum and is used primarily as an anti staphylococcal agent... 

Rivastigmine Transdermal (Exelon Patch) [Cholinesterase Inhibitor/Anti-Alzheimer Agent] Uses MUd/mod Alzheimer and Parkinson Dz dementia Action Acetylcholinesterase inhibitor Dose Initial 4.6-mg patch/d applied to back, chest, upper arm, T 9.5 mg after 4 wk if tolCTated Caution [ ] Sick sinus synd, conduction defects, asthma, COPD, urinary obst, Sz Contra Hypersensitivity to rivastigmine, other carbamates Disp Transdermal patch 5 cm (4.6 mg/24 h), 10 cm (9.5 mg/24 h) SE NA /D EMS See Rivastigmine OD See Rivastigmine... 

Compared with conventional NSAIDs, they are no more effective as anti-inflammatory agents. Many properties are quite similar, including potential for nephrotoxicity and hypersensitivity. 

In the last few years, interest in triterpenes as anti-inflammatory agents and their mechanisms of action has also increased greatly. Oleanolic acid and ursolic acid have been recognised to have anti-inflammatory activity in carrageenan-induced paw edema in rats or mice, adjuvant-induced arthritis in rats, etc. Oleanolic acid, in addition, was able to suppress the delayed hypersensitivity reaction in mice induced by dinitrochlorobenzene (DNCB). These effects are attributable to different mechanisms of action ranging from the inhibition of histamine release to inhibition of complement activity [1,58]. 

The pulmonary toxic changes produced by anti-neoplastic agents show a structure of morphological and clinical manifestations, including noncar-diogenic pulmonary oedema and pneumonitis/fib-rosis. Hypersensitivity reactions may be associated with eosinophilic infiltration and usually lead to little residual damage. 

Erythromycin, Ophthalmic (llotycin Ophthalmic) [Anti-intective, Macrolide, Opthalmic agent] Uses Conjunctival/comeal Infxns Action Macrolide antibiotic Dose 1/2 in 2-6 X /d Caution [B, +] Contra Erythromycin hypersensitivity Disp Qint SE Local irritation EMS See Erythromycin may cause burning, stinging, blurred vision... 

The primary adverse effect of intravenous cidofovir is a dose-dependent nephrotoxicity. Concurrent administration of other potentially nephrotoxic agents (eg, amphotericin B, aminoglycosides, nonsteroidal anti-inflammatory drugs, pentamidine, foscarnet) should be avoided. Prior administration of foscarnet may increase the risk of nephrotoxicity. Other potential side effects include uveitis, decreased intraocular pressure, and probenecid-related hypersensitivity reactions. Neutropenia and metabolic acidosis are rare. The drug caused mammary adenocarcinomas in rats and is embryotoxic. 

D-Penicillamine is used in the treatment of rheumatoid arthritis. Several types of pulmonary toxicities have been described with this agent. A pulmonary-renal syndrome similar to Goodpasture s syndrome has been rarely described and is fatal in 50% of the cases. Hemoptysis and hematuria are present in an acute fashion and warrant prompt discontinuation of the drug. Anti-glomerular basement membrane antibodies are not found and the role of plasmapheresis in undetermined. Treatment with corticosteroids or immunosuppressive agents may be of benefit (21). Bronchiolitis obliterans with or without organizing pneumonia has also been reported, but is also described with rheumatoid arthritis. Hypersensitivity pneumonitis and the subacute onset of pulmonary fibrosis have been... 

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