Anti-Helicobacter agents

Drugs required to exert local therapeutic action in the stomach misoprostol, 5-fluorouracil, antacids and antireflux preparations, anti Helicobacter pylori agents, and certain enzymes. 

Diketonates include [Bi(ACAC)3]," and [Bi(dpm)3]." Tropolone derivatives have attracted interest as anti-Helicobacter pylori agents. Various types are known, including [Bi2(N03)2(trop)4] (tropH = tropolone) which is a dimer (Figure 64), [Bi(trop)2(H20)]N03, [BiPh(trop)2], and [Bi(trop)4] all of which are essentially monomers. ... 

Peptic ulcer disease is associated with Helicobacter pylori infection in 90% of patients with gastric and duodenal ulceration. Elimination of H. pylori infection with antibiotics heals the peptic ulcer and the associated symptoms. Combination therapy with antibiotics, anti-secretory agents, namely H2-receptor antagonists or proton pump inhibitors, and bismuth salts has significantly improved the clinical outcome of peptic ulcer disease. Not all strains of H. pylori cause peptic ulcer disease, and other factors are necessary for H. pylori colonization and disease to occur. Flagellated motile bacteria resist peristalsis and adhere to gastric epithelium in a highly specific manner. 

Kubo, J., Lee, J.R., and Kubo, L, Anti-Helicobacter pylori agents from the cashew apple, J. Agric. Food... 

Helicobacter pylori is a bacterium that lives in the human stomach and duodenum. The bacterium is generally recognized as one of the etiological agents of peptic ulcer. Therefore, it is generally accepted that ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to anti-secretory drugs, whether on first... 

The American cranberry (Vaccinium macrocarpon Ait (Ericaceae)) was used by North-American Indians to fight urinary tract infections and other bacterial diseases. Proanthocyanidins, present in cranberries as oligomers of catechin and epicatechin, inhibit the docking of bacteria on tissues in vitro an anti-adhesive mechanism of cranberry-proanthocyanidins (Howell et al. 2001). The efficacy of cranberry juice and extracts as a prophylactic agent against recurrent urinary infections is well documented in women (Stothers 2002). The anti-adhesion effect of cranberry-proanthocyandins can also be applied for treatment of other common diseases of bacterial pathogenesis, e.g. Helicobacter py/on-associated gastritis and dental caries/periodontal disease (Nowack 2007). 

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