Anti-genotoxic

Barcelo S, Gardiner JM, Gesher A and Chipman JK. 1996. CYP2El-mediated mechanism of anti-genotoxicity of the broccoli constituent of sulforaphane. Carcinogenesis 17 277—282. 

S.O. Mueller, M. Schmitt, W. Decant, FI. Stopper, J. Schlatter, P. Schleier and W.K. Lutz, Occurrence of emodin, chrysophanol and physcion in vegetables, herbs and liquors. Genotoxicity and anti-genotoxicity of the anthraquinones and of the whole plants. Food Chem. Toxicol. 37 (1999) 481 -91. 

Urgert, R., M. P. M. E. W. Van Der Wouw, R. Hovenier, P. G. Lund-Larsen, and M. B. Katan. Chronic consumers of boiled coffee have elevated serum levels of lipoprotein (A). J Intern Med 1996 240(6) 367-371. Abraham, S. K. Anti-genotoxic effects in mice after the interaction between coffee and dietary constituents. Food Chem Toxicol 1996 3(1) 15-20. Urgert, R., M. P. M. E. Weusten-Van Der Wouw, R. Hovenier, S. Meyboom,... 

CYP [antimutagenic, anti-genotoxic, block xenobiotic conversion to genotoxics] CYP - CYP3A4 (17)... 

Capsaicin is a natural compound that has been described as both anti-genotoxic and anti-carcinogenic. In addition, it is surmised to have a potential chemopreventive activity [119]. The compound s antiinflammatory properties have been demonstrated in different in vivo pharmacological tests, which have shown that it inhibits, among others, carrageenan-induced inflammation in rats and croton oil-induced mouse ear edema. These effects are associated with its interference of phospholipase A2 (PLA2), the enzyme that produces arachidonic acid from the membrane phospholipids. Moreover, the proapoptotic effects of capsaicin are widely documented in the literature [120]. 

Zamorano-Ponce, E., J. Fernandez, G. Vargas, P. Rivera, and M. A. Carballo. 2004. Protective activity of cedron Aloysio triphylla) infusion over genetic damage induced by cisplatin evaluated by the comet assay technique. Toxicol. Lett. 152(l) 85-90. Zamorano-Ponce, E., C. Morales, D. Ramos, et al. 2006. Anti-genotoxic effect of Aloysio triphylla infusion against acrylamide-induced DNA damage as shown by the comet assay technique. Mutat. Res. 603(2) 145-150. 

Perez-Carreon, J.I., G. Cruz-Jimenez, J.A. Licea-Vega, et al. 2002. Genotoxic and anti-genotoxic properties of Calendula officinalis extracts in rat liver cell cultures treated with diethylnitrosa-mine. Toxicol. In Vitro 16 (3) 253-258. 

Abraham, S.K., S.R Singh, and P.C. Kesavan. 1998. In vivo anti-genotoxic effects of dietary agents and beverages co-admin-istered with urethane Assessment of the role of glutathione S-transferase activity. Mutat. Res. 413(2) 103-110. 

Romero-Jimenez, M., J. Campos-Sanchez, M. Analla, A. Munoz-Serrano, and A. Alonso-Moraga. 2005. Cenotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat. Res. 585(1-2) 147-155. 

Recently, many in oitro test systems have been successfully applied to estimate the mutagenic, clastogenic and recombinegenic properties of manmade and naturally occurring chemicals. These rapid and economic bioassays can also be used to uncover the anti-genotoxic and by implication anticarcinogenic activity of compounds... 

The following attempts were made to gain at least some insight into the possible role of phenolic-containing food items as anti-genotoxic agents. 

Abraham SK (2001) Anti-genotoxicity of trans-anethole and eugenol in mice. Food Chem Toxicol 39 493 98... 

Species/extract Against Assay Cell types Genotoxic Anti- genotoxic References... 

Limiting the genotoxicity of bile acids might be alforded by interventions including anti-oxidant supplementation in susceptible patient groups. 

APIs are chemicals that have been optimized for intended biological effect, minimal undesired side effects, and stability. Stability is essential for long shelf-life. However, this is not always successful as some APIs are also mutagenic, genotoxic, or carcinogenic, such as some compounds used in anti-cancer treatment. After their... 

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