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Genetic damage

May cause heritable genetic damage May cause birth defects... [Pg.448]

Genetic damage can take place at the level of the chromosome or at the gene level. In addition, chemicals can also induce alterations in the number of chromosomes in the cells. Aneuploidy is an excess or a shortage of a single chromosome. Polyploidia is an excess of a whole set of chromosomes tn the ceil. [Pg.289]

Genotoxicity studies are required to identify compounds that can induce genetic damage ranging from single point gene mutations to gross alterations of chromosomal structure. Such effects are taken as indicative of the potential to cause cancer or heritable defects in humans. A standard battery of three types of test is recommended ... [Pg.66]

Davis M Mescaline excitatory effects on acoustic startle are blocked by serotonin 2 antagonists. Psychopharmacology (Berl) 93 286—291, 1987 DishotskyNI, LoughamWD, Mogar RE, et al LSD and genetic damage. Science 172 431 40, 1971... [Pg.238]

Whittier JB, McBee K. 1999. Use of flow cytometry to detect genetic damage in mallards dosed with mutagens. Environ Toxicol Chem 18(7) 1557-1563. [Pg.237]

Because of these important properties, a future application of HS can be expected as protecting agents for the prevention or at least limitation of genetic damages that may be caused by genotoxic environmental pollutants in plants, and also in microorganisms, animals, and even humans. [Pg.299]

Ieradi, L.A., M. Cristaldi, D. Mascanzoni, E. Cardarelli, R. Grossi, and L. Campanella. 1996. Genetic damage in urban mice exposed to traffic pollution. Environ. Pollut. 92 323-328. [Pg.333]

Lamb, T., J.W. Bickman, J.W. Gibbons, M.J. Smolen, and S. McDowell. 1991. Genetic damage in apopulation of slider turtles (Trachemys scripta) inhabiting a radioactive reservoir. Arch. Environ. Contam. Toxicol. 20 138-142. [Pg.1745]

Straume, T., T.C. Kwan, L.S. Goldstein, and R.L. Dobson. 1991. Measurement of neutron-induced genetic damage in mouse immature oocytes. Mutat. Res. 248 123-133. [Pg.1750]


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