Compound structurally related

Naturally occurring compounds with carbon-metal bonds are very rare The best example of such an organometallic compound is coenzyme Bi2 which has a carbon-cobalt ct bond (Figure 14 4) Pernicious anemia results from a coenzyme B12 deficiency and can be treated by adding sources of cobalt to the diet One source of cobalt IS vitamin B12 a compound structurally related to but not identical with coen zyme B12... 

Figure 25. Survey of compounds structurally related to clonidine (46)...

Ishikawa, H., W. J. Schubert, and F. F. Nord The Enzymatic Degradation of Softwood Lignin by White Rot Fungi. The Degradation by Polyporus versicolor and Forties fomentarius of Aromatic Compounds Structurally Related to Softwood Lignin. Arch. Biochem. Biophys. 100, 131-149 (1963). 

Another compound structurally related to the oxicams is RU 43526 (159) [387], which gave approximately equipotent inhibition of seminal vesicle CO (2.1 //M) and of rat ISN (3.0 //M). Removal of the 2-substituent had no effect on the CO inhibition, but drastically reduced 5-LO potency. RU 43526 was orally active, but only in NSAID-sensitive models (CPE 4 mg/kg, RAA 0.7 mg/kg). It was unknown whether the 5-LO inhibition made any contribution to the anti-inflammatory activity of this compound. 

There is some controversy as to whether the frogs produce the toxins themselves as secondary metabolites or whether they are simply processing their food - ants. Dendrobatid frogs raised in captivity lose their toxicity. In fact, chemical analyses of ants similar (but not identical) to those found in the natural habitat show compounds structurally related to the toxins. 

Ethers are organic compounds structurally related to alcohols. The oxygen atom in an ether group, however, is bonded not to a carbon and a hydrogen but rather to two carbons. As we see in Figure 12.14, ethanol and dimethyl ether have the same chemical formula, C2H(50, but their physical properties are vastly different. Whereas ethanol is a liquid at room temperature (boiling point 78°C) and mixes quite well with water, dimethyl ether is a gas at room temperature (boiling point —25°C) and is much less soluble in water. 

Amphetamines are a family of compounds structurally related to the neurotransmitters norepinephrine and dopamine. 

The proton spectra for the dibenzo derivatives, viz. dibenzo[6,e][l,4]dioxin, phenoxathiin and thianthrene, have been reported in full, as part of a wider survey of heterocyclic compounds structurally related to anthracene. The protons in dibenzo[6,e ][ 1,4]dioxin are the most shielded, and in phenoxathiin the protons ortho and para oriented to the C—O bond are shielded relative to those ortho and para to sulfur <740MR(6)U5). The 13C chemical shifts for phenoxathiin follow a similar pattern, with carbons ortho and para to the C—O bond resonating at 117.5 and 124.2 p.p.m. respectively, and at higher field than those ortho, para to the C—S bond (127.4 and 126.5 p.p.m.), in good agreement with shifts predicted on the basis of additivity effects <73JMR(12)143). 

Pijper, P. J. Synthesis and Antimycoplasmal Activity of Compounds Structurally Related to 2,2 -Bipyridyl. Ph.D. Thesis, Free University Amsterdam 1980... 

Dezocine is a compound structurally related to pentazocine. It has its highest affinity for receptors and less interaction with receptors. Although it is said to be equivalent in efficacy to morphine, its use is associated with the same problems observed with all opioids that have mixed receptor actions. 

The term ecdysteroid was originally defined as "all compounds structurally related to ecdysone" [4], However, Lafont and Horn [5] differentiated between true ecdysteroids and ecdysteroid-related compounds. True ecdysteroids possess a steroid nucleus with an A/B-cis-ring junction and a 14a-hydroxy-7-en-6-one chromophore, irrespective of their biological activity, while ecdysteroid-related compounds do not fulfil all these criteria. 

That receptors 22a and 22b contain an inwardly directed hydrogen bond acceptor is not directly evident. These compounds structurally relate to cavitand 3 in that they contain amide groups at three aromatic resides, which stabilize the cavitand s vase conformation by intramolecular hydrogen bond formation. The remaining aromatic wall contains an appended Kemp s triacid residue such that its free carboxyl group is oriented toward the inside of the cavity. 

Acid halides are compounds structurally related to oxy-aeids by substitution of halogen atoms for OH groups. The acid chlorides are the most important ... 

Due to the importance of modified nucleosides that are also in the base, the development of new biocatalytic processes appUed to the synthesis of derivatives modified in the base is of great interest Adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are biocatalysts that catalyze the hydrolytic deaminahon of purine nucleosides and nucleotides. Some applications of these deaminases for the preparation and transformation of compounds structurally related to nucleosides with potential antitumor and antiviral activities have been described in the last few years [8]. 

Mandelate racemase, which is probably the best known of all racemizing enzymes [10], shows an activity limited to compounds structurally related to man-delates [11]. The presence of an aromatic group or an unsaturation in the a-position is essential for activity. 

Degraded Carotenoids. Syntheses have been reported for several compounds structurally related to carotenoids. Many of the procedures used may be relevant to the construction of carotenoid end-groups. 

Meyer and Schwartz, in a study of model compounds structurally related to heparin, showed that the hydrolytic release of sulfate under acid conditions from 2-amino-2-deoxy-D-glucose A -sulfate is more rapid than from D-glucose 6-0-sulfate. These workers also obtained a biologically inactive, nitroso derivative of heparin, and offered this as evidence for a sulfamic acid linkage in the molecule. Wolfrom, Shen and Summers prepared methyl 2-amino-2-deoxy-A-sulfo-tri-0-sulfo-(3-D-glucopyranoside dibarium salt, and found that, on heating a 3 X 10 M solution in 0.004 N hydrochloric acid, the A-sulfate is lost in 20 minutes and the 0-sulfate after 12 hours. 

An Y NMR study has also been made of the effect of Y2O3 on the sintering of the silicon aluminium oxynitride 3-sialon, a compound structurally related to (3-Si3N4 but... 

MMDA (methoxymethylenedioxyamphetamine) is a phenylethylamine compound structurally related to amphetamine and mescaline. It is a potent psychotropic (hallucinogenic) but is not used in therapeutics. It is a drug of abuse. 

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