Aneurine

Thiamine [59-43-8] is the official lUPAC-IUB name for 3-(4-aniiQO-2-methyl-5pyrimidiQyl) methyl-5-(-2-hydroxyethyl)-4-methylthia2olium chloride, C 2H yN40SCl (1). The names thiamine, thiamin (used in many official and commercial documents), aneurine, and the older term vitamin are also casually used. These names usually refer to the chloride hydrochloride [67-03-8] (2), the common biological and commercial form. 

Cocarboxylase tetrahydrate (aneurine pyrophosphoric acid tetrahydrate, thiamine pyrophosphoric acid tetrahydrate) [136-09-4] M 496.4, m 220-222°(sinters at 130-140°), 213-214°, pKes,(1)-2, pKeskd O pKesi(3) 9- Recrystd from aqueous Me2CO. [Wenz et al. Justus Liebigs Ann Chem 618 210 7955 UV Melnick J Biol Chem 131 615 1939 X-ray Carlisle and Cook Acta Cryst (B) 25 1359 1969.] The hydrochloride salt has m 242-244°(dec), 241-243°(dec) or 239-240°(dec) and is... 

D Aneurin A.S. (A.S.) Betabion (Merck) Lophakomp (Lomapharm) Vitamin Bj Hevert (Hevert) Vitamin Bplnjektopas (Pascoe)... 

In 1948, when the NHS was established by the then Minister of Health, Aneurin Bevan, during the Labour Government of Clement Attlee, all prescriptions were supplied free of charge. A charge of Is Od ( 0.05) per prescription, irrespective of the number of items, was eventually introduced in 1952. Shortly after this the charge was changed to Is Od ( 0.05) per item on the prescription. ... 

In such circumstances I sometimes imagine myself in the position of the then Foreign Secretary who found himself subject to the withering scorn of Aneurin Bevan who, in the Suez debate in parliament in 1957, felt that the Foreign Secretary was not in command of his material in the same way that his predecessor (Anthony Eden, who was now Prime Minister) would have been. Some of you may remember ... 

The group of B vitamins consists of thiamine or aneurine (vitamin B i), riboflavin (vitamin B2), nico-... 

THIAMINE (Vitamin Bi). Some earlier designations for this substance included aneurin, antmeuntic factor, antibenben factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP). the formula of which is ... 

Those older men and women exercising structural and moral authority (Paterson, 1966), often called collectively the Establishment, have been alarmed by psychedelics for rather less than five years. Their attitude might be described in the terms Aneurin Bevan used for an old man approaching a young bride "... fascinated, sluggish, and apprehensive."... 

Common Name Aneurine Bl-Vitamin Oryzanin Thiamine chloride Torulin Structural Formula ... 

Aneurine Hydrochloride Thiamine Chloride Vitamin Vitamin Bi Hydrochloride... 

As shown in Figure 6.1, thiamin consists of pyrimidine and thiazole rings, linked by a methylene bridge the alcohol group of the side chain can be esterified with one, two, or three phosphates, yielding thiamin monophosphate, thiamin diphosphate (also known as thiamin pyrophosphate, the metabolically active coenzyme), and thiamin triphosphate. The vitamin was originally named aneurine, the antineuritic vitamin, because of its function in preventing or... 

Thiamine is a water-soluble vitamin and is also known as vitamin Bi, or aneurin (Fig. 1). Both the pyrimidine and thiazole moieties are necessary for biological activity, which is maximal when only one methylene group bridges the two moieties. 

Synonyms. Aneurine Mononitrate Thiamine Nitrate Vitamin B, Mononitrate. 

Aneurine chloride hydrochloride, 1014 Aneurine mononitrate, 1015 Aneurone, 976, 1014 AnfotericinaB, 350 Angiers, 361... 

SYNS 3-((4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL)-5-(2-HYDROXYETHYL)-4-METHYL-THIAZOLIUM CHLORIDE ANEURINE APATATE DRAPE B-AMIN BEIVON BETABION BETAL-IN S BETAXIN BETHIAMIN BEWON ORYZANIN ORYZANINE THIAMIN THIAMINE MONOCHLORIDE VINOTHIAM VITAMIN B1 VITANEURON... 

In Chemical Abstracts, abstracts on the vitamin itself are indexed under the letter used to designate that vitamin, but derivatives are indexed under the chemical name of the vitamin. For example, vitamin Bi is listed as such under vitamin, but the ethyl derivative is listed under aneurine, ethyl. More about indexing and the difficulties involved appears in Crane s paper. A beautiful Job of cross indexing is found in Chemical Abstracts. The searcher should follow up all of these cross references, and on some subjects should add a few of his own topics, particularly where a broad field is being covered. For example, in extensive literature search on the agglomeration of fine particles the following subjects were covered in Chemical Abstracts ... 

Vitamin Bj Vitamin Bj was discovered in 1926 by Jansen and Do-NATH, who synthesized it in its crystalline form from rice bran. It was initially called aneurine due to its antipolyneuropathic effect. Because it contains sulphur, Windaus correctly renamed it thiamine in 1932, a term by which it is still known today. The stixicture of this vitamin was described by Williams and Grewe in 1936. It is made up of pyrimidine and thiazole. Thiamine occurs in nature as free thiamine and in the form of thiamine monophosphate, diphosphate and triphosphate. A maximum amount of 8 — 15 mg is absorbed daily in the proximal portion of the small intestine. In the case of oversupply, thiamine is neither stored nor intestinally absorbed. A regular intake, with a daily requirement of about 1 mg, is necessary. The major coenzyme is thiamine pyrophosphate (TPP). Thiamine deficiency may be caused by malnutrition, impaired absorption, alcoholism, antithiamines or a lack of magnesium. Magnesium is an important cofactor for the coenzyme thiamine pyrophosphate. 

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