Chloride channel, thiamin triphosphate

Later studies established the coenzyme role of thiamin diphosphate in transketolase in the pentose phosphate pathway. More recent studies have shown that thiamin triphosphate acts to regulate a chloride channel in nerve tissue. 

Early studies showed that thiamin triphosphate had a role in electrical conduction in nerve cells more recent smdies have shown that it activates a chloride channel in the nerve membrane, acting as a phosphate donor (Bettendorff... 

Elecfiical stimulation of a wide range of nerve preparations results in thiamine release suggesting a role for the vitamin in membrane function that is independent of its enzyme cofactor role mediated by TDP. TDP is further phosphorylated to thiamine triphosphate (Fig. 2). Although its precise role has yet to be elucidated, it has been proposed that TTP activates high-conductance chloride channels (Bettendorf,... 

Thiamin triphosphate is involved in the activation of the chloride ion channel in the membranes of nerves, possibly by phosphorylation of the channel protein. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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