Carcinoma anaplastic thyroid

Ordonez NG, El-Naggar AK, Hickey RC, Samaan NA. Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases. Am Clin Pathol. 1991 96 15-24. [Pg.255]

Poorly differentiated thyroid carcinomas of the insular type are usually TGB positive, although the extent of cellular staining is generally weak and focal.Undifferentiated (anaplastic) thyroid carcinomas are most commonly negative for TGB. In the series reported by... [Pg.299]

Antibodies to T3 and T4 have been used less extensively than TGB in studies of thyroid carcinoma. Kawaoi and coworkers reported T4 positivity in 95% of papillary carcinomas and 54% of follicular carcinomas but in no cases of anaplastic thyroid carcinoma. T3 was present in 66% of papillary carcinomas, 81% of follicular carcinomas, and 45% of anaplastic carcinomas. The significance of T3 staining in the absence of T4 immunoreactivity, however, is unknown. In addition to thyroglobulin, T3, and T4, thyroid peroxidase has also been used for studies of thyroid tumors. ... [Pg.299]

Vimentin is coexpressed with cytokeratins in the vast majority of normal and neoplastic thyroids. In the series of Miettinen and colleagues, follicular and papillary tumors expressed vimentin in more than 50% of the tumor cells. Immunoreactivity for vimentin was generally present in the basal portions of the cells in contrast to the more diffuse cytoplasmic reactivity for cytokera-tins. Vimentin immunoreactivity has been reported in 94% of anaplastic thyroid carcinomas. [Pg.301]

Carcangiu ML, Zampi G, Rosai J. Poorly differentiated ( insular ) thyroid carcinoma A reinterpretation of Langhans wuchernde Struma. Am J Surg Pathol. 1984 8 655-668. Ordonez NG, El-Naggar AK, Hickey RC, Samaan NA. Anaplastic thyroid carcinoma Immunocytochemical study of 32 cases. Am J Clin Pathol. 1991 96 15-24. [Pg.331]

Wiseman SM, Griffith OL, Deen S, et al. Identification of molecular markers altered dtrring transformation of differentiated into anaplastic thyroid carcinoma. Arch Surg. 2007 142 717-729. [Pg.332]

Lim YC, Cha YY (2011) Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroid carcinoma cells through suppression of EGFR/ERK pathway and cyclin Bl/CDKl complex. J Surg Oncol 104 776-780... [Pg.2236]

Bravo, S.B., Garcia-Rendueles, M.E.R., Seoane, R., Dosil, V., Cameselle-Teijeiro, J., Lopez-Lazaro, L., Zalvide, J., Barreiro, F., Pombo, C.M., and Alvarez, C.V. (2005) Plitidepsin has a cytostatic effect in human undifferentiated (anaplastic) thyroid carcinoma. Clin. Cancer Res., 11, 7664-7673. [Pg.871]

Positive in almost all thyroid carcinomas, with reduced immunostaining of poorly differentiated carcinoma to complete absence in anaplastic types... [Pg.227]

Ordonez and coworkers,5 of 32 (15.6%) cases of anaplastic carcinoma exhibited TGB immunoreactivity in a small number of cells using both monoclonal antibodies and polyclonal antisera. In this series, positivity was present in 3 of 8 giant cell, 1 of 4 spindle cell, and none of 6 squamoid or 13 mixed variants. Examination of serial sections in these cases failed to reveal evidence of entrapped normal follicular cells or foci of differentiated thyroid carcinoma. Other authors, however, have failed to demonstrate any TGB immunoreactivity in anaplastic carcinomas except in foci of residual differentiated tumor. [Pg.299]

Thyroid transcription factor-2 (TTF-2) and PAX-8, which are essential for thyroid organogenesis and differentiation, have also been studied in thyroid tumors. TTF-1, TTF-2, and PAX-8 were expressed in differentiated and poorly differentiated thyroid carcinomas, whereas TTF-1 and TTF-2 were expressed in 18% and 7% of anaplastic carcinomas, respectively. PAX-8, on the other hand, was present in 79% of anaplastic carcinomas. TTF-2 was negative in all other neoplastic and non-neoplastic tissues including those of pulmonary origin. Although PAX-8 was present in a variety... [Pg.300]

FIGURE 10.12 A, Anaplastic (undifferentiated) thyroid carcinoma (H E stain). B, Immunoperoxidase stain for broad-spectrum cytokeratins (AE1 /AE3) shows cytoplasmic staining. [Pg.302]

Approximately 15% of poorly differentiated thyroid carcinomas and a significantly higher proportion of undifferentiated/anaplastic carcinomas are positive for BRAE mutations.Moreover, the mutations occur more commonly in those poorly differentiated and undifferentiated carcinomas with a papillary component. These findings suggest that the high-grade tumors progress from BRAF-positive papillary carcinomas. [Pg.309]

Follicular and papillary thyroid carcinomas are the most common endocrine malignancies. Follicular, papillary and anaplastic carcinoma are derived from follicular epithelium of thyroid gland, but characterized by different histological appearance, different biological and clinical behavior and associated with different genetic abnormalities. [Pg.206]

One-dimensional MR spectra (Fig. 2) for 107 thyroid biopsies were analysed in this study, including 11 normal (N), 13 papillary carcinomas (PC), 4 other carcinomas (anaplastic, medullary), and 73 follicular adenomas, of which 10 were clinically manifest as follicular carcinoma (FC).46... [Pg.82]

Nikiforova MN, Kimura ET, Gandhi M, et al. BRAE mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab. 2003 88 5399-5404. [Pg.56]

Nuclear immunostaining in all carcinomas of thyroid origin (except anaplastic type)... [Pg.227]

Thyroid transcription factor-1 (TTF-1), a nuclear tissue-specific protein transcription factor, is found in thyroid and thyroid tumors regardless of histologic type (except anaplastic type), as well as in lung carcinomas including adenocarcinomas (75%), non-small cell carcinomas (63%), neuroendocrine and small cell carcinomas (>90%), and squamous cell carcinomas (10%).258-258 Selectively expressed during embryogenesis in the thyroid, the diencephalon of the brain, and in respiratory epithelium, TTF-1 binds to and activates factors for surfactant protein derived from Clara cells.255 TTF-1 is rarely seen in carcinomas outside of the lung or thyroid... [Pg.227]

Adenocarcinoma, thyroid (note 100 anaplastic carcinomas of thyroid are less frequently positive) Carcinoma, small cell, vaginal 34... [Pg.376]

Hard or unusual firmness in one region of the goiter raise the suspicion of cancer, parficularly anaplastic carcinoma or thyroid lymphoma... [Pg.326]

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