Ether, anaesthetic

Synonyms Aether AI3-24233 Anaesthetic ether Anesthesia ether Anesthetic ether Diethyl ether Diethyl oxide EINECS 200-467-2 Ether Ethoxyethane Ethyl oxide NSC 100036 l,l -0 Qr-bis(ethane) RCRA waste number U117 Solvent ether Sulfuric ether UN 1155. 

Amresco acryl-40, see Acrylamide AMS, see a-Methylstyrene n-Amyl acetate, see Amyl acetate Amyl acetic ester, see Amyl acetate Amyl acetic ether, see Amyl acetate Amylene, see 1-Pentene a-n-Amylene, see 1-Pentene p-n-Amylene, see cis-2-Pentene cis-p-Amylene, see cis-2-Pentene frans-p-Amylene, see trans-2-Venlene sec-Amyl ethanoate, see Amyl acetate Amyl ethyl ketone, see 5-Methyl-3-heptanone Amyl hydride, see Pentane Amyl methyl ketone, see 2-Heptanone n-Amyl methyl ketone, see 2-Heptanone AN, see Acrylonitrile Anaesthetic ether, see Ethyl ether Anamenth, see Trichloroethylene Anduron, see Diuron Anesthenyl, see Methylal Anesthesia ether, see Ethyl ether Anesthetic ether, see Ethyl ether Anhydrous ammonia, see Ammonia Aniline oil, see Aniline Anilinobenzene, see 4-Aminobiphenyl Anilinomethane, see Methylaniline 2-Anidine, see o-Anisidine 4-Anisidine, see p-Anisidine 2-Anisylamine, see o-Anisidine... 

In theory, induction should be rapid, but in practice the inspired vapour concentration must be increased slowly to avoid airway irritation. MAC is 1.15% in 100% oxygen and 0.56% in 30% oxygen, making it less potent than halothane (0.75% and 0.29% at these oxygen concentrations). Isoflurane is the most potent of all the currently available anaesthetic ethers. Recovery from isoflurane anaesthesia is rapid and clear and the drug is suitable for use in day surgery. Cardiovascular system... 

Anaesthetic Ether B.P) is highly purified ether containing not more than 0.002% w/v of a stabiliser such as propyl gallate or hydroquinone. 

SYNS AETHER ANAESTHETIC ETHER ANESTHESIA ETHER ANESTHETIC ETHER DIAETHYL, ETHER (GERMAN) DIETHYL ETHER pOT) DIETHYL OXIDE DWUETYLOWT ETER (POLISH) ETERE ETILICO (ITALIAN) ETHER ETHER ETHYLIQUE (FRENCH) ETHOXYETHANE l,l -OXYBISETHANE OXYDE d ETHYLE (FRENCH) RCRA WASTE NUMBER LT17 SOLVENT ETHER... 

There are limitations to the use of this particular equation. For example, it is derived purely for anaesthetic ethers and is not applicable to other structural types of anaesthetics. This is generally true in QSAR studies. The procedure works best if it is applied to a series of compounds which have the same general structure. 

Since different anaesthetics have similar logP0 values, the logP value of any compound can give some idea of its potential potency as an anaesthetic. For example, the log P values of the gaseous anaesthetics ether, chloroform, and halothane are 0.98, 1.97, and 2.3 respectively. Their anaesthetic activity increases in the same order. 

Drugs exhibit a number of possible hazards in addition to toxicity. Anaesthetic ether (diethyl ether, 60-29-7) forms extremely explosive and poisonous substances on exposure to atmospheric oxygen sodium hypochlorite and hydrogen peroxide used as antiseptics are oxidizers multiple acids, metals, metal salts, and bases are used. In addition, drugs are rarely administered pure. Instead, they are coupled with solvents, diluents, solutions, and administered by aerosol sprays, etc., which may represent hazards. 

Transfer an amount of the powdered tablets equivalent to 25 mg of amphetamine sulphate to a separator containing 30 ml of water and 5 ml of O IN sodium hydroxide and shake to dissolve. Extract with four 30-ml portions of anaesthetic ether and wash the combined ether extracts with 2 ml of water. Run the ether solution into a wide-mouthed flask containing 20 ml of O IN sulphuric acid and evaporate the ether on a water-bath. Cool, transfer to a 50-ml graduated flask and make up to volume with 0-1N sulphuric acid. Centrifuge a portion of the solution and measure the maximum extinction of a 1 -cm layer of the clear supernatant liquid at about 257 mfJi using O IN sulphuric acid as reference and calculate the percentage of amphetamine sulphate in the original sample. 

Dissolve 0 25 g in 2 ml of anaesthetic ether and dilute to exactly IQO ml with analytical-reagent grade dehydrated methanol. Transfer a 10-ml aliquot of this solution to a 150-ml separator and continue by the method for capsicum beginning with the words add 15 ml of the dehydrated methanol, 15 ml of water. . ... 

The B.P.C. method, based upon the work of Hampshire and Page, does not enjoy the confidence of the majority of workers in this field, particularly in its assay for water-soluble alkaloids. The B.P.C. method consists in mixing the dried fat-free drug with ammonia and anaesthetic ether and then extracting the alkaloids by continuous extraction with the latter solvent. Some acetone is added to the ethereal solution (this helps to prevent emulsions in the subsequent extraction) and the alkaloids are extracted with a 1 per cent solution of tartaric acid. Total alkaloids are determined by treating an aliquot portion of the acid solution with di-methylaminobenzaldehyde reagent (see below). Water-insoluble alkaloids are then determined in a second portion of the acid solution by extracting... 

Middleton and Hymas summarised all previous tests proposed for the detection of peroxides present in the quantities usually met with in anaesthetic ether and studied their relative values for experimental work. The sensitivities of twenty different methods were compared both for hydrogen peroxide and ether peroxide. As the best quantitative method would be that in which the intensity of colour is most nearly proportional to the amount of peroxide present, and observable over a wide range, the ferrous thiocyanate method (sensitive to 0-017 p.p.m. ether peroxide and 0-025 p.p.m. hydrogen peroxide) was eventually chosen as most suitable. 

Weigh 1 to 5 g of the sample, finely ground, transfer to a conical flask with 50 ml of N hydrochloric acid, cover the flask with a small beaker and autoclave at 121° (15 lb steam pressure) for fifteen minutes. Cool, add 2 ml of 2 5M sodium acetate solution and adjust to pH 4-5 using bromocresol green as external indicator. Dilute to 100 ml with water, filter and extract an aliquot with anaesthetic ether. Adjust to pH 6-8 using bromothymol blue as external indicator and dilute as required so that the final solution contains about 01 mg nicotinic acid per ml. Proceed with the assay as described in Appendix VII on Microbiological Assays (p. 813). 

To 01 g in a separator add 25 ml of freshly boiled and cooled water, and 25 ml anaesthetic ether and rotate until dissolved. Add 2 ml of freshly prepared, saturated sodium carbonate solution and shake. Allow to separate, run the lower layer into a second separator and transfer the... 

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