Amygdala lesions

Gay, P.E., and Cole, S.O. Interactions of amygdala lesions with effects of pilocarpine and [Pg.92]

Roozendaal B, McGauglr JL (1997) Basolateral amygdala lesions block die memory-enhancing effect of glucocordcoid adminisda-don in die dorsal hippocampus of rats. Eur J Neurosci 9 76-83. 

Ritter S. Hutton B. Mercaptoacetate-induced feeding is impaired by central nucleus of the amygdala lesions. PhysiolBehav 1995 58 1215-1220. 

Prather MD, Lavenex P, Maudlin-Jourdain ML, Mason WA, Capitanio JP, Mendoza SP, Amaral DG (2001) Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. Neuroscience 106 653-658. 

Stone VE, Baron-Cohen S, Calder A, Keane J, Young A (2003) Acquired theory of mind impairments in individuals with bilateral amygdala lesions. Neuropsychologia 41 209-220. 

For surgery 20 control females were anaesthetized at the age of 165 days with an intraperitoneal injection of 45 mg/kg of ketamine. Ibotenic acid (IBO) was stereotaxically injected into the dorsal hippocampi (10 jUg IBO in 0.5 jul of phosphate buffer into each hemisphere). Ten additional females were treated alike without IBO injection (sham operation). For amygdala lesions 0.4 jUg IBO in 0.4 jul phosphate buffer were stereotaxically injected into each side. 

The deficit induced by amygdala lesions at the age of 500 days was similar to that induced by lead, in that there was an increase in time to make eight correct choices in comparison to controls by either kind of treatment. Testing for retention also revealed similar behaviour between lead-exposed and lesioned animals. This outcome must be considered preliminary as the histological examination is not yet complete. In addition to the deficit exhibited by lesioned and lead-treated rats, and in contrast to all previous age points, there was a significant (p < 0.05) difference between permanently and maternally exposed rats at this age in the acquisition part. 

Deminiere, J.M. Taghzouti, K. Tassin, J.P. Le Moal, M. and Simon, H. Increased sensitivity to amphetamine and facilitation of amphetamine selfadministration after 6-hydroxydopamine lesions of the amygdala. Psychopharmacology 94 232-236, 1988. 

Demas G.E., Williams J.M. and Nelson R.J. (1997). Amygdala but not hippocampal lesions impair olfactory memory for mate in prairie voles (Microtus ochrogaster). Am J Physiol 273, 1683-1689. 

Kirkpatrick B., Carter C Newman S. and Insel T. (1994). Axon-sparing lesions of the medial nucleus of the amygdala decrease affiliative behaviors in the prairie vole (Microtus ochrogaster) — behavioral and anatomical specificity. Behav Neurosci 108, 501-513. 

Petrulis A. and Johnston R. (1999). Lesions centered on the medial amygdala impair scent-marking and sex-odor recognition, but spare discrimination of individual odors in female golden hamsters. Behav Neurosci 113, 345-357. 

Davis M, Myers KM (2002) The role of glutamate and gamma-aminobutyric acid in fear extinction clinical implications for exposme therapy. Biol Psychiatry 52 998-1007 Davis M, Whalen PJ (2001) The amygdala vigilance and emotion. Mol Psychiatry 6 13-34 Davis M, Hitchcock JM, Bowers MB, Berridge CW, Meha KR, Roth RH (1994) Stress-induced activation of prefrontal cortex dopamine turnover blockade by lesions of the amygdala. Brain Res 664 207-210... 

Kelsey, John E.,and Susan R. Arnold. 1994."Lesions of the Dorsomedial Amygdala, but Not the Nucleus Accumbens, Reduce the Aversiveness of Morphine Withdrawal in Rats." Behavioral Neuroscience 108 1119-27. 

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