Hippocampus dorsal

Morioka, T., Kalehua, A.N. and Streit, W.J. (1991). The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 11, 850-859. 

We have evaluated the dose-related effects of PCP, ketamine, and selected anticonvulsant drugs on seizure activity in the hippocampal model of kindled seizures. The hippocampal model is particularly well suited for the study of the anticonvulsant effects of drugs because of the slow rate of acquisition of the fully kindled seizure. Electrical stimulation of the dorsal hippocampus initially evokes a stereotyped sequence of behavior, accompanied by a characteristic EEG pattern. Repeated electrical stimulation eventually results in generalized kindled seizures. This allows the testing of drugs on the unkindled hippocampal seizure (afterdischarge) to be compared to effects on the fully kindled seizure in the same rats. 

Male, Sprague-Dawley rats were implanted under pentobarbital anesthesia with a bipolar electrode in the right dorsal hippocampus for hippocampal stimulation and recording. Stainless steel screws were also placed over the contralateral frontal and parietal cortices for recording cortical seizure activity. The electrodes... 

Kenny, P.J.F.S., Rattray, M. Nicotine regulates 5-HT 1Areceptor gene expression in the cerebral cortex and dorsal hippocampus. Eur. J. Neurosci. 13 1267, 2001. 

Benveniste H, Drejer J, Schousboe A, Diemer NH. 1987. Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat. J Neurochem 49(3) 729-734. 

Matsuo M, Kataoka Y, Mataki S, Kato Y, Oi K (1996) Conflict situation increases serotonin release in rat dorsal hippocampus In vivo study with microdialysis and Vogel test. 

Blum S, Adams AN, Dash PK (1999) A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosci 19 3535-3544... 

Similarly, intrahippocampal injections of 8-OH-DPAT induced no change in performance levels of the rat trained to run in a radial maze (Buhot et al. 1995). However, the intrahippocampal injection of the 5-HTjg receptor agonist CP-93,129 [3-(l,2,5,6-tetrahydropyrid-4-yl] pyrrolo [3,2-6] pyrid-5-one] induced a higher frequency of reference memory errors than of working memory. It was concluded that stimulation of 5-HT,g receptors in the CAl field of the dorsal hippocampus impairs performance of rats in a spatial learning task. 

The injection of scopolamine into the dorsal hippocampus of the rat impaired choice accuracy in a two-platform spatial discrimination task. The subcutaneous injection of ondansetron antagonized the effect of scopolamine but had no effect when administered alone (Carli et al. 1997). A working memory task with a three-panel runway arrangement showed that the concurrent infusion of the S-ffTj receptor antagonist Y-25130 and scopolamine into the dorsal hippocampus of the rat significantly attenuated the impairment induced by scopolamine. Y-25130 administered alone had no effect and failed to block the impairment induced by the NMDA receptor antagonist ( )-3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (Ohno and Watanabe 1997). 

Collard KJ, Roberts MHT Effects of lithium on the elevation of forebrain 5-hydroxyindoles by tryptophan. Neuropharmacology 16 671-673, 1977 Console S, Bertorelh R, Russi G, et al Serotonergic facihtation of acetylchohne release in vivo from rat dorsal hippocampus via serotonin S-HTj receptors. J Neurochem 62 2254-2261, 1994... 

DeKloet ER, Kovacs GL, Szabo G, et al Decreased serotonin turnover in the dorsal hippocampus of rat brain shortly after adrenalectomy selective normalization after corticosterone substitution. Brain Res 239 659-663, 1982 Del Zompo M, Bernadi F, Burrai C, et al A double-blind study of minaprine versus amitriptyline in major depression. Neuropsychobiology 24 79-83, 1991 Delespaul PhAEG Schizophrenics in Daily Life. Maastricht, Universiteitspers Maastricht, 1995... 

Ji, J., and Maren, S. (2005). Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learn. Mem. 12, 270—276. 

Thompson, L. T., and Best, P. J. (1990). Long-term stability of the place-field activity of single units recorded from the dorsal hippocampus of freely behaving rats. Brain Res. 509, 299-308. 

Bosker FJ, van Esseveldt KE, Klompmakers AA, Westenberg HG. Chronic treatment with fluvoxamine by osmotic minipumps fails to induce persistent functional changes in central 5-HT1A and 5-HT1B receptors, as measured by in vivo microdialysis in dorsal hippocampus of conscious rats. Psychopharmacology 1995 117 358-363. 

Luttgen M, Ove Ogren S, Meister B. Chemical identity of 5-HT2A receptor immunoreactive neurons of the rat septal complex and dorsal hippocampus. Brain Res 2004 1010 156-165. 

Bosker FJ, Dewinter TYCE, Klompmakers AA, Westenbeig HGM. Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors. J Neu-rochem 1996 66 2546-2555. 

Tada K, Kasamo K, Ueda N, Suzuki T, Kojima T, Ishikawa K. Anxiolytic 5-hydroxytryptamine 1A agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism single-unit study in unanesthetized, unrestrained rats. J Pharmacol Exp Ther 1999 288 843-848. 

Hervas I, Queiroz CM, Adell A, Artigas F. Role of uptake inhibition and autore-ceptor activation in the control of 5-HT release in the frontal cortex and dorsal hippocampus of the rat. Br J Pharmacol 2000 130 160-166. 

HT afferents projecting to individual terminal areas. Thus, the effects of SSRIs in areas with predominate innervation from the dorsal raphe are augmented by 5-HT1A receptor antagonists or in 5-HT1A / mice, such as the frontal cortex and striatum, but are less effective (or not at all) in the median raphe-innervated dorsal hippocampus. 

Debonnel, G., Beauchesne, L., and de Montigny, C. 1989a. Domoic acid, the alleged mussel toxin, might produce its neurotoxic effect through kainate receptor activation an electrophysiological study in the dorsal hippocampus. CanJ Physiol Pharmacol 67, 29-33. 

Debonnel, G., Weiss, M., and de Montigny, C. 1989b. Reduced neuroexcitatory effect of domoate following mossy fibre denervation of the rat dorsal hippocampus further evidence that toxicity of domoic acid involves kainate receptor activation. Can J Physiol Pharmacol 67, 904-908. 

Roozendaal B, McGauglr JL (1997) Basolateral amygdala lesions block die memory-enhancing effect of glucocordcoid adminisda-don in die dorsal hippocampus of rats. Eur J Neurosci 9 76-83. 

Patel, P. M., Drummond, J. C., Mitchell, M. D., Yaksh, T. L., and Cole, D. J., Eicosanoid production in the caudate nucleus and dorsal hippocampus after forebrain ischemia a microdialysis study, J. Cereb. Blood Flow Metab., 12, 88, 1992. 

---