Amphetamines Schedule 3 drug

Racemic f/zreo-methylphenidate was approved for the treatment of fatigue, nausea, and depression in 1955 under the brand name Ritalin , and was first used in children in 1958 with an approval for hyperkinetic disorder (ADHD) in 1960. Methylphenidate has an even shorter half-life than amphetamine, and its use in treating ADHD was limited by the fact that schoolchildren would need to visit a nurse during the day to take a second dose of this scheduled drug (in order to maintain efficacy throughout the entire school day). In humans, injecting methylphenidate produces effects similar to intravenous cocaine, but oral methylphenidate is adsorbed very slowly from the gut into the blood and takes an unusually long time (estimated 2.5 h) to reach a peak concentration... 

Schedule II—The drug or other substance has (1) a high potential for abuse, (2) a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions, and (3) abuse of the drug or other substances may lead to severe psychological or physical dependence. Examples cocaine, PCP, morphine, fentanyl and meperidine, codeine, amphetamine and methamphetamine, Ritalin . 

Chewing leaves of the khat shrub is practiced in parts of East Africa and the Arabian peninsula (Kalix 1988 Widler et al. 1994). Some estimate daily use at 5 million portions. Use in the West is less common, but has increased somewhat. More common in the United States has been use of the synthetic drug methcathinone (or "cat"), which is derived from khat alkaloids. Only the fresh khat leaves are pharmacologically active, so for some time use was limited to local areas that grew the plant. However, with air transportation, use has spread with emigrants in Europe and the United States. Because of its pharmacological similarities to amphetamine and its addictive properties, khat has been listed on Schedule I of the United Nations Convention on Psychotropic Substances. 

Schedule 2 includes drugs such as dia-morphine (heroin), morphine, pethidine, quin-albarbitone, glutethimide, amphetamine and cocaine and which are subject to the full controlled drug requirements relating to prescriptions, safe custody (except for quinalbarbitone), the need to keep registers, etc. (unless exempted in Schedule 5). 

Schedule III Substances with less potential for abuse than drugs in Schedule I or II for example, methyl-phenidate, amphetamine, secobarbital, and anabolic steroids. 

Amphetamine, a Schedule II drug, was synthesized by the German chemist . Edeleano in 1887 (Figure 6.2). The trade names for amphetamine are Benzedrine and Dexedrine. Smith, Kline, and French marketed Benzedrine inhaler in the 1930s for respiratory disorders. Since amphetamine decreases drowsiness and fatigue, it is marketed for narcolepsy and attention-deficit/hyperactivity disorder (ADHD), and was used as an appetite suppressant (anorectic) in diet regimens. Amphetamine was supplied to the... 

EXTENSIONS AND COMMENTARY In the 1960 s there was quite a bit of interest in a couple of pharmaceutical houses with the indole analogues of amphetamine. Both the alpha-methylated tryptamine (this compound, a-MT) and the alpha-ethylated homologue (a-ET, see its separate recipe) were found to be effective monoamine oxidase inhibitors, and both were clinically studied as potential antidepressants. The ethyl compound became a commercial drug, offered by the Upjohn Company as Monase, but now is considered to be without medical use and is a Schedule I drug. It is interesting that this methyl compound, a-MT was also a medically available antidepressant in the Soviet Union in the 1960 s and was sold under the name of Indopan, in 5 and 10 milligram tablets. 

Schedule II - The drugs at this level also have a high abuse potential and could cause psychic or physical dependence. They may be prescribed but are under stringent control. Schedule II drugs include opioids(morphine), amphetamines and methamphetamines used alone or in combination as well as some barbiturates. 

Schedule 3 involves drugs with a significant abuse potential, but lower than for Schedules 1 and 2. Such drugs may lead to moderate or low physical dependence or high psychological dependence. Examples include many stimulants such as amphetamines and methamphetamines as well as various barbiturates. Anabolic steroids (used by athletes and bodybuilders) are also included because of their serious health risks. 

Since 1971, the DEA, the agency responsible for the regulation and control of substances with potential for abuse, has classified Ritalin in the Schedule II category of drugs, together with cocaine, amphetamines, methamphetamine... 

Schedule 11 drugs have a high potential for abuse, but some medical use, and include, morphine, codeine, barbiturates, and amphetamines. 

One of the most controversial CNS-acting drugs in contemporary society is methylphenidate (Ritalin ). This drug is structurally related to amphetamine and is a mild stimulant that has abuse potential similar to amphetamine. Methylphenidate is classified as a Schedule II controlled substance. It is effective in the treatment of narcolepsy and attention-deficit hyperactivity disorder (ADHD). Its use in ADHD has caused the greatest controversy. 

In 2000, in response to continuing drug company pressure to view Ritalin as a mild stimulant, the DEA s Christine Sannerud and Gretchen Feussner wrote an article asking Is Ritalin an Abused Drug Does It Meet the Criteria of a Schedule II Substance They documented that Ritalin is similar in its effects to amphetamine and cocaine ... 

Mendrek A, Blaha CD, Phillips AG (1998) Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule. Psychopharmacology 735(4) 416-422. 

F Many diet pills contain ephedrine or caffeine. Amphetamines are Schedule II drugs and may not be sold without a prescription. 

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