Aminoglycosides dosing

Routine use of once-daily aminoglycosides in CF is not recommended and should be limited to adults and older teens, in whom the time below the MIC can be minimized. Due to a shorter half-life, once-daily aminoglycoside dosing does not appear to be optimal for use in younger children. 

Assess serum creatinine and aminoglycoside serum concentrations if the patient is being treated with an aminoglycoside. Adjust aminoglycoside dose based on serum concentrations target peak concentration with multiple doses per day = 6 mcg/mL (12.54 pmol/L). 

Uses Prevent skin Infxn Action Topical aminoglycoside Dose Apply to skin and rub in Caution [C, /-] Contra Component aU gy Disp Cream SE Itching, rash, redness EMS See Neomycin Sulfate OD Unlikely... 

In a retrospective study in 81 men and 29 women, hearing loss of 15 decibels at two or more frequencies, or at least 20 decibels at at least one frequency, was found in 18% of patients treated with aminoglycosides (amikacin, kanamycin, and/or streptomycin) (24). In those treated with kanamycin the rate was 16%. Age, sex, treatment duration, total aminoglycoside dose, and first serum creatinine concentration were not associated with hearing loss. 

Rybak MJ, Abate BJ, Kang SL, Ruffing MJ, Lerner SA, Drusano GL. Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob Agents Chemother 1999 43(7) 1549-55. 

Parker SE, Davey PG. Practicahties of once-daily aminoglycoside dosing. J Antimicrob Chemother 1993 31(l) 4-8. 

Reeves DS, MacGowan AP. Once-daily aminoglycoside dosing. Lancet 1993 341(8849) 895-6. 

Kotler DP, SordiUo EM. Nutritional status and aminoglycoside dosing. Qin Infect Dis 1998 26(l) 249-52. 

Chuck SK, Raber SR, Rodvold KA, Areff D. National survey of extended-interval aminoglycoside dosing. Chn Infect Dis 2000 30(3) 433-9. 

Conventional and once-daily aminoglycoside dosing regimens... 

Hatala R, DinhT, Cook DJ, Once-daily aminoglycoside dosing in immunocompetent adults, Ann Int Med, 1996 124(8) 717-25. Ferriols-Lisart R, Alos-Alminana M, Effectiveness and safety of once-daily aminoglycosides a meta-analysis. Am J Health Syst Pharm, 1996 53(10) 1141 -50. 

Kemme DJ, Daniel Cl, Aminoglycoside dosing a randomized prospective study. South Med J, 1993,86(1) 46-51. 

Martin JE, Commentary once-daily aminoglycoside dosing where are we now , J Crit Care, 2003,18(2) 107-13. 

Zhanel, G.G. (1993) Once daily aminoglycoside dosing the result of research on antimicrobial pharmacodynamics. American Journal of Pharmaceutical Education, 56, 156-167. 

University hospital Pharmacokinetic monitoring To evaluate impact of computer-assisted aminoglycoside dosing 4.09 1... 

Koup JR, Killen T, Bauer LA. Multiple-dose nonlinear regression analysis program Aminoglycoside dose prediction. Chn Pharmacokinet 1983 8 456 62. 

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