Aminoglycosides daily dosing

Data for once-daily dosing of aminoglycosides for children exist, but no data for treatment of IE exist. 

Aminoglycosides are often used in patients with gram-negative bacillary pneumonia. Single daily dosing may be of particular importance in patients with pneumonia, since this regimen can increase the peak concentration of the aminoglycosides in bronchial secretions. 

Once-daily dosing has potential practical advantages. For example, repeated determinations of serum concentrations are probably unnecessary unless aminoglycoside is given for more than 3 days. A drug administered once a day rather than three times a day saves time. And once-a-day dosing lends itself to outpatient therapy. 

In vivo PAEs are usually much longer than in vitro PAEs. This is thought to be due to postantibiotic leukocyte enhancement (PALE) and exposure of bacteria to subinhibitory antibiotic concentrations. The efficacy of once-daily dosing regimens is in part due to the PAE. Aminoglycosides and quinolones possess concentration-dependent PAEs thus,... 

Other potentially nephrotoxic drugs (e.g, nonsteroidal antiinflammatory drugs) should be used with caution in patients receiving gentamicin therapy, Data for once-daily dosing of aminoglycosides for children exist, but no data for treatment of infective endocarditis exist. 

PLATINUM COMPOUNDS AMINOGLYCOSIDES, CAPREOMYCIN, COLISTIN, STREPTOMYCIN, VANCOMYCIN t risk of renal toxicity and renal failure and of ototoxicity. The ototoxicity tends to occur when cisplatin is administered early during the course of aminoglycoside therapy Additive renal toxicity Monitor renal function prior to and during therapy, and ensure an intake of at least 2 L of fluid daily. Monitor serum potassium and magnesium and correct any deficiencies. Most side-effects of aminoglycosides are dose-related, and it is necessary to t interval between doses and 1 dose of aminoglycoside if there is impaired renal function... 

Freeman CD, Nicolau DP, Belliveau PP, Nightingale CH. Once-daily dosing of aminoglycosides Review and recommendations for clinical practice. J Antimicrob Chemother 1997 39 677-86. 

Twice-daily or thrice-daily administration was for a long time standard in aminoglycoside therapy of systemic bacterial infections in patients with normal renal function. However, in vitro, in vivo, and clinical studies have suggested that once-daily dosing of the same total daily dose might be more beneficial with respect to both efficacy and toxicity (SEDA-21, 265) (149-152). 

Buijk SE, Mouton JW, Gyssens IC, Verbrugh HA, Bruining HA. Experience with a once-daily dosing program of aminoglycosides in critically ill patients. Intensive Care Med 2002 28(7) 936 2. 

Barclay ML, Bfirkpatrick CM, Begg EJ. Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored Clin Pharmacokinet 1999 36(2) 89-98. 

Aminoglycoside antibiotics Once-daily dosing [125] Monitoring of drug levels... 

BarzaM, loannidisJPCapelleri JC, Lau J, Sing le or multiple daily doses of aminoglycosides a meta-analysis, BMJ, 1996 312(7027) 338-44. 

Galloe AM, Graudal N, Christensen EIR, Kampmann JP, Aminoglycosides single or multiple daily dosing, Eur J Pharmacol, 1995 48 39-43. 

Bailey TC, Eittle JR, Eittenberg B, Reichhiey RM, Dunagan WC, A meta- analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides, Clin Infect Dis, 1997 24 786-95. 

---