Aminoglycosides extended-interval dosing

Bailey TC, Little JR, Littenberg B. A meta analysis of extended-interval dosing vs multiple dosing of aminoglycosides. Clin invect Dis 1997 24 786-795... 

Bailey TC, Eittle JR, Eittenberg B, Reichhiey RM, Dunagan WC, A meta- analysis of extended-interval dosing versus multiple daily dosing of aminoglycosides, Clin Infect Dis, 1997 24 786-95. 

The monitoring of serum concentrations of aminoglyco- sides and the use of extended-interval doses of aminoglycosides can help to maximize the probability of therapeutic success and minimize the probability of aminoglycoside-related toxicity. 

Traditional methods of aminoglycoside serum concentration monitoring (evaluating peak and trough serum concentrations) cannot be applied to extended-interval dosing... 

Adverse reactions to aminoglycosides, including nephrotoxicity, ototoxicity, and neuromuscular blockade, in patients in intensive care have been reviewed [3 ]. The use of a high-dose extended interval dosing regimen may reduce the incidence of acute kidney damage in one study the incidence was 1.2%, which is lower than the previously reported rate of 3-5%. 

Chuck SK, Raber SR, Rodvold KA, Areff D. National survey of extended-interval aminoglycoside dosing. Chn Infect Dis 2000 30(3) 433-9. 

McNamara DR, Nafziger AN, Menhinick AM, Bertino JS. Jr. A dose-ranging study of gentamicin pharmacokinetics implications for extended interval aminoglycoside therapy. J Clin Pharmacol 2001 41(4) 374-7. 

Because they are hepatically cleared, isoniazid and rifampin do not require dose modification in renal failure.31,36,39 Pyrazinamide and ethambutol typically are reduced to three times weekly to avoid accumulation of the parent drug (ethambutol) or metabolites (pyrazinamide).28,31 Renally cleared TB drugs include the aminoglycosides (e.g., amikacin, kanamycin, and streptomycin), capreomycin, ethambutol, cycloserine, and lev-ofloxacin.28,31,33,39 Dosing intervals need to be extended for... 

---