Alzheimer s disease risk factors

Treusch, S., Hamamichi, S., Goodman, J.L., et al. Functional Links Between A Toxicity, Endocytic Trafficking, and Alzheimer s Disease Risk Factors in Yeast. Science 334(80), 1241-1245 (2011). doi 10.1126/science.l213210... 

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McCusker SM, Curran MD, Dynan KB, McCullagh CD, Urquhart DD, Middleton D et al. Association between polymorphism in regulatory region of gene encoding tumour necrosis factor a and risk of Alzheimer s disease and vascular dementia a case-control study. Lancet 2001 357 436 139. 

In addition, haplotype-based methods can increase the power of association studies since the allelic architecture of the risk factor is unknown. Recent examples of association studies suggest that haplotypes can be the responsible factors [58]. The Apo E4 allele , which is associated with Alzheimer s disease, is a possible example since it results from the substitution of two of non-conservative polymorphisms encoding for residues 112 and 158 [59]. 

Alzheimer s disease is the most common form of age-related dementia and one of the most serious health problems in the industrialized world. AD is an insidious and progressive neurodegenerative disorder that accounts for the vast majority of dementia and is characterized by global cognitive decline and the accumulation of P-amyloid deposits and neurofibrillary tangles in the brain. Family history is the second greatest risk factor for... 

Sorbi, S., et al., "Genetic Risk Factors in Familial Alzheimer s Disease," Mech Ageing Dev., 122, 1951-1960 (2001). 

Golanska E, Hulas-Bigoszewska K, Wojcik I, Rieske P, Styczynska M, et al. 2005. CYP46 a risk factor for Alzheimer s disease or a coincidence Neurosci Lett 383 105-108. 

Cacabelos, R., Fernandez-Novoa, L., Lombardi, V., Corzo, L., Pichel, V., Kubota, Y. (2003) Cerebrovascular risk factors in Alzheimer s disease Brain hemodynamics and pharmacogenomic implications. Neurol. Res., 25, 567-580. 

Borroni, B., Archetti, S., Agosti, C., et al. (2004) Intronic CYP46 polymorphism along with APOE genotype in sporadic Alzheimer s disease from risk factors to disease modulators. Neurobiol. Aging, 25, 747-751. 

Mace, S., Cousin., E, Rrcard, S., et al. (2005) ABCA2 is a strong genetic risk factors for early-onset Alzheimer s disease. Neurobiol. Dis., 18, 119-125. 

Myllykangas, L., Polikoski, T., Sulkava, R., et al. (2000) Cardiovascular risk factors and Alzheimer s disease a genetic association study in a popular aged 85 or over. Neurosci. Lett., 292, 195-198. 

Table 10.1 shows the proposed risk factors for Alzheimer s disease, the most common cause of dementia. Heading this list is of course old age. But be careful how you... 

Of considerable biochemical interest, several factors are associated with Alzheimer s disease but their significance is not known. An elevated plasma level of homocysteine is associated with the disease and it is considered as a risk factor for development of the disease. The damage may be caused by a degradation product of homocysteine a thio-lactone which causes oxidative damage to cells (Chapter 22 see Figure 22.7). 

Neurodegeneration High plasma levels of homocysteine are a risk factor for Alzheimer s disease. There are two mechanisms by which homocysteine could damage neurones. 

Kumar V, Anand R, Messina J, et al An efficacy and safety analysis of Exelon in Alzheimer s disease with concurrent vascular risk factors. Eur J Neurol 7 159-169, 2000... 

I must admit that I was intrigued as I flipped through the journal and encountered repeated references to pH — here was something a chemist could really sink his teeth into. Scientists routinely use the pH scale to measure the acidity of a solution, be it blood, wine, or tap water but I never realized that the wrong pH could be killing us. Yet that is exactly what the Vaxa Journal contends. The pH Factor The Real Silent Killer, reads the headline. The solution to longevity is simple pop a Buffer-pH capsule daily and lower your risk of heart disease, stroke, cancer, obesity, multiple sclerosis, and Alzheimer s disease. 

Polidori M. C. (2004). Oxidative stress and risk factors for Alzheimer s disease clues to prevention and therapy. J. Alzheimer s Dis. 6 185-191. 

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