Risk factors genetic

The majority of people who smoke never develop lung cancer. Genetic risk factors may predispose certain smokers to lung cancer. After adjustments for age, smoke exposure, occupation, and gender, relatives of a lung cancer patient have approximately a twofold risk of developing lung cancer. The... 

Moatti D, Faure S, Fumeron F, et al. Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. Blood 2001 97(7) 1925-1928. 

Ghilardi G, Biondi ML, Turri O, Guagnellini E, Scorza R. Internal carotid artery occlusive disease and polymorphisms of fractalkine receptor CX3CR1 a genetic risk factor. Stroke 2004 35(6) 1276-1279. 

Frosst P, Blom HJ, Milos R et al. A candidate genetic risk factor for vascular disease a common mutation in methylene-tetrahydrofolate reductase. Nature Genet 1995 10 111-113. 

Cigarette smoking is responsible for about 80% of lung cancer cases. Other risk factors include exposure to respiratory carcinogens (e.g., asbestos, benzene), genetic risk factors, and history of other lung diseases (e.g., tuberculosis, pulmonary fibrosis). 

These results suggest that the taxon is overinclusive It includes 28% of low-risk participants—instead of the 10% predicted by Meehl s theory—and misses some cases that later become symptomatic. This might mean that the identified taxon is not isomorphic with specific genetic liability for schizophrenia and reflects a construct that is overlapping, but not identical to, the genetic risk factor. Another explanation is that the DSM criteria for schizophrenia and spectrum conditions may be too broad. Tyrka et al. (1995) proposed this hypothesis and estimated that at least two-thirds of the misses (symptomatic cases not assigned to the taxon) can be accounted for by errors in the taxon classification scheme, but the remaining misses are due to... 

Sorbi, S., et al., "Genetic Risk Factors in Familial Alzheimer s Disease," Mech Ageing Dev., 122, 1951-1960 (2001). 

The role of Lp(a) as a primary genetic risk factor for coronary heart disease, therefore, seems firmly established. However, in blacks, despite mean Lp(a) levels twice as high as in whites, the incidence of cardiovascular disease is apparently identical (G37, S40). The role of Lp(a) in atherosclerotic vascular disease in blacks therefore remains to be established. 

Charron, P., Tesson, E., Poirier, O., et al. (1999) Identification of a genetic risk factor for idiopathic dilated cardiomyopathy. Involvement of a polymorphism in the endothehn receptor type A gene. CARDIGENE group. Eur. Heart J. 20, 1587-1591. 

Mace, S., Cousin., E, Rrcard, S., et al. (2005) ABCA2 is a strong genetic risk factors for early-onset Alzheimer s disease. Neurobiol. Dis., 18, 119-125. 

Dementia has reached epidemic proportions with an estimated 4.6 million new cases worldwide each year... it is a true disease, cause by exposure to several genetic and non-genetic risk factors. 

However, similar to studies of adults that show common familial and genetic risk factors for anxiety and depression (Kendler et al. 1996 Merikangas 1990 Stavrakaki and Vargo 1986), studies in children have also revealed a lack of specificity of parental anxiety and/or depression (Beidel and Turner 1997 Sylvester et al. 1988 Turner et al. 1987 Warner et al. 1995b). 

Environmental stimuli and context are relevant to the occurrence of aggression. The interaction between environment and genetic risk factors may offer new opportunities for intervention. For example, individuals with family histories of suicide are at increased risk for suicide. However, even individuals with low levels of 5-HI A A generally do not make daily or even monthly attempts—so what is it that relates to an attempt happening on one day and not another Maes et al. (1995)... 

Comings, David E., L. Ferry, S. Bradshaw-Robinson, R. Burchette, C. Chiu, and Donn Muhleman. 1996a. "The Dopamine D2 Receptor (DRD2) Gene A Genetic Risk Factor in Smoking." Pltarmacogenetics 6 73-79. 

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