Aluminum ferrule

Investigation into the vial manufacturing process was initiated to determine the root cause of the contamination. The vials are most commonly glass, since this provides an inert contact surface and transparency for inspection and dose verification. The vials must be sealed, and at one end a piston must be provided while at the opposite end a septum is fitted to allow puncture by the needle inside the syringe barrel. The elastomeric components of both are shown in Figure 10-1 and Figure 10-2. An aluminum ferrule that is crimped to form a seal after the vial is filled surrounds the diaphragm. 

Phosphorized deoxidized arsenical copper (alloy 142 (23)) is used for heat exchangers and condenser tubes. Copper-arsenical leaded Muntz metal (alloy 366), Admiralty brass (alloy 443), naval brass (alloy 465), and aluminum brass (alloy 687), all find use in condensers, evaporators, ferrules, and heat exchanger and distillation tubes. The composition of these alloys is Hsted in Table 5. 

The metered valve crimped on an aluminum can (anodized or plastic coated) glass bottle creates the uniqueness of the MDI dosage form. The dimensions of the valve parts related to the crimp, such as ferrule and gasket thickness... 

Ferrule An aluminum cup that holds the valve components together and attaches them to the can in the crimping process. 

The metering valve in an MDI is the critical component in the design of an effective delivery system. The main function of the metering valve is to reproducibly deliver a portion of the liquid phase of the formulation in which the medication is either dissolved or dispersed. The valve also forms the seal atop the canister to prevent loss of the pressurized contents. The valves generally comprise at least seven components that are constructed from a variety of inert materials. Typical materials of construction are acetal or polyester for the valve body, stainless steel or acetal for the valve stem, generally anodized aluminum for the ferrule, and butyl, nitrile, or neoprene for the elastomers used in the seals and gaskets [43],... 

Along the same line, an aluminum capillary lined with quartz coated with carbon black has been evaluated for the analysis of amines. Volatile Organic Compounds (VOCs), and oil products (25). In an alternative stainless steel column format (non-glass-lined stainless steel) intfoduced by Agilent Technologies, the metal column is deactivated and thus provides inertness similar to that of fused silica. Columns of this nature, termed DB-ProSteel series, have the same o.d. as that of a standard megabore column (0.53 mm i.d.) and require no special ferrules. 

Example It Aircraft Fuel line IGC Inspections revealed fuel line corrosion beneath ferrules (Fig. 6). The cause of the corrosion was traced to die fuel line marking process, which involved electrolytic labelii of ferrul aluminum alloy 6061-T6 tubes. Although subsequent rinsing of the fuel lines washed off most of the electrolyte, some was trapped between the 6061-T6 tubing and the ferrule. This condition made corrosion of the fuel lines inevitable. 

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