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Pharmaceutical alternatives

Rowan, A. (1981). The LD50 Test A critique and suggestions for alternatives. Pharmaceutical... [Pg.174]

An alternative pharmaceutical gear extruder, similar in design to the above, has recently been marketed by G.B. Caleva Ltd., United Kingdom. [Pg.1726]

Reformulation of drugs used in pMDIs to avoid CFC propellants presented numerous obstacles, because no approved alternative pharmaceutical propellants were available. " Replacement of the propellants used in pMDIs requires changes in many fundamental aspects of formulation, device design, device components, and manufacturing. Several classes of propellants have been considered as alternatives for... [Pg.2106]

Nuijen B, Bouma M, Schellens JH, Beijnen JH. Progress in the development of alternative pharmaceutical formulations of taxanes. Invest New Drugs 2001 May 19(2) 143-153. [Pg.281]

Hexanetriol, is used in a variety of pharmaceutical and cosmetics industry appHcations and is currendy viewed as an alternative to glycerol as... [Pg.128]

Talc is sold for use in a wide variety of appHcations, including paper (qv), ceramics (qv), roofing, paint (qv), plastics, mbber (qv), cosmetics (qv), pharmaceuticals (qv), adhesives (qv), sealants (qv), and animal feedstuffs (see Feeds and feed additives). In all of these appHcations it is a functional ingredient with specific beneficial properties. Talc is rarely used as a filler because it is much more expensive than alternative minerals such as limestone and clay. [Pg.301]

Michael P. Thien, Se.D., Senior Research Fellow, Merck Co., Inc. Member, American Institute of Chemical Engineers, American Chemical Society, International Society for Pharmaceutical Engineers (Section 22, Alternative Separation Processes)... [Pg.17]

Mathews and Rawlings (1998) successfully applied model-based control using solids hold-up and liquid density measurements to control the filtrability of a photochemical product. Togkalidou etal. (2001) report results of a factorial design approach to investigate relative effects of operating conditions on the filtration resistance of slurry produced in a semi-continuous batch crystallizer using various empirical chemometric methods. This method is proposed as an alternative approach to the development of first principle mathematical models of crystallization for application to non-ideal crystals shapes such as needles found in many pharmaceutical crystals. [Pg.269]

For food and pharmaceutical applications, the microbial count must be reduced to less than 10,000 viable cells per g exopolysaccharide. Treatment with propylene oxide gas has been used for reducing the number of viable cells in xanthan powders. The patented process involves propylene oxide treatment for 3 h in a tumbling reactor. There is an initial evacuation step before propylene oxide exposure. After treatment, evacuation and tumbling are alternated and if necessary the reactor is flushed with sterile nitrogen gas to reduce the residual propylene oxide level below the Food and Drug Administration permitted maximum (300 mg kg 1). The treated polysaccharide is then packaged aseptically. [Pg.211]

Fermentation broths are complex, aqueous mixtures of cells, comprising soluble extracellular, intracellular products and any unconverted substrate or unconvertible components. Recovery and extraction of product is important in bioprocess engineering. In particular separation is a useful technique it depends on product, its solubility, size of the process, and product value. Purification of high-value pharmaceutical products using chromatography such as hormones, antibody and enzymes is expensive and difficult to scale up.1 Tire necessary steps to follow a specific process depend on the nature of the product and the characteristics of the fermentation broth. There are a few steps for product recovery the following processes are discussed, which are considered as an alternative for product recovery from fermentation broth. [Pg.170]

Where small quantities of high-purity steam is required for electronic chip, pharmaceutical, sterilization, food preparation, and similar process applications, a small risk of steam contamination may exist. This may be caused directly by the use of amine treatments or indirectly through process contaminants or the transport of iron oxides. Consequently, alternative arrangements for steam generation are made. [Pg.60]

AOPs are valuable tertiary treatments allowing not only inactivation of a wide spectrum of pathogens but also the removal of a great number of the so-called emerging pollutants (pharmaceutical, personal care products). These are not totally removed during conventional treatment, but remain in the wastewater effluents [33]. Among different alternatives electrochemical oxidation with bom doped diamond electrodes (BDD) has been reported to be effective on eliminating... [Pg.112]

The need of modern science to achieve a sustainable future development has been shown in many circumstances in society. Finding strategies less harmful to the environment has been a quest for research in several areas, such as pharmaceuticals, biotechnology, and food industries. With that purpose, the increase in research and development of more applications of xylan and its derivatives has shown the versatility of this biopolymer, thus helping the search for sustainable alternatives. [Pg.78]

Dilithiated diphenyl ether reacts with heteroaiyl esters to give 9-substituted xanthen-9-ols, offering an alternative approach to pharmaceuticals containing a 9-xanthylidene unit <96TL5073>. [Pg.299]

Since the 1993 court decision against Barr Laboratories, 5 tjjg elimination of outliers has taken on a decidedly legal aspect in the U.S. (any non-U.S. company that wishes to export pharmaceuticals or preciwsor products to the U.S. market must adhere to this decision concerning out-of-specifica-tion results, too) the relevant section states that ... An alternative means to invalidate an individual OOS result... is the (outlier test). The court placed specific restrictions on the use of this test. (1) Firms cannot frequently reject results on this basis, (2) The USP standards govern its use in specific areas, (3) The test cannot be used for chemical testing results. ... A footnote explicitly refers only to a content uniformity test, 5 but it appears that the rule must be similarly interpreted for all other forms of inherently precise physicochemical methods. For a possible interpretation, see Section 4.24. [Pg.61]

The importance of producing pharmaceuticals in enantiomerically pure forms was brought to the public s attention with the thalidomide (Formula 4.2) tragedy in the early 1960s. Thalidomide, as a racemic mixture, was originally produced in 1953 as a sedative and a non-addictive alternative to barbiturates. It was later found that it alleviated many of the unpleasant symptoms of early pregnancy but by 1961 its use had been linked with an increase in the number of severe birth deformities and it was withdrawn. It... [Pg.113]


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See also in sourсe #XX -- [ Pg.15 , Pg.98 ]




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