Propyl allyl disulfide

In rats, the LCso for 8 hours was 670 ppm effects were lacrimation, nasal discharge, dyspnea, and narcosis. In rats repeatedly exposed to 600 ppm for 8 hours daily, effects were pronounced irritation of the eyes and respiratory tract more than half of the rats developed corneal opacity at necropsy, after 25 exposures, pulmonary findings were inflammation, bronchiectasis, and bronchopneumonia. [Pg.35]

Inhalation of 7 ppm for 6 hours/day caused necrosis and complete erosion of nasal mucosa after 4 days squamous metaplasia of the respiratory epithelium and focal erosion of the olfactory epithelium with evidence of regeneration of some epithelial surface occurred in mice after 9-14 days at this exposure level. Rats and mice exposed to concentrations as low as 4 ppm for 13 weeks had squamous metaplasia, hyperplasia, and inflammation of the nasal mucosa. [Pg.35]

AGE was mutagenic in some strains of bacteria with or without metabolic activation. It also induced sister chromatid exchanges and chromosomal aberrations in cultured cells. [Pg.35]

Percutaneous absorption has been documented in rabbits. The liquid dropped into the eye of a rabbit caused severe but reversible conjunctivitis, iritis, and corneal opacity. Cytotoxic effects on rat bone marrow cells, with reduction in leukocyte counts, and testicular degeneration were observed after intramuscular injections at 400mg/kg/day. [Pg.35]

The 2003 ACGIH threshold limit valuetime-weighted average (TLV-TWA) for allyl glycidyl ether is 1 ppm (4.7 mg/m ). [Pg.35]

Toxicology. Allyl propyl disulfide vapor is a mucous membrane irritant. [Pg.36]

Allyl propyl disulfide was not mutagenic in Salmonella typhimurium assays with or without activation. ... [Pg.36]

Allyl glycldyl ether Allyl propyl disulfide alpha-Alumlna Aluminum alkyls Aluminum metal and oxide Aluminum pyro powders Aluminum soluble salts Aluminum welding fumes 4-Aminodlphenyl 2-Aminopyrldlne Amilrole Ammonia... [Pg.408]

CHRONIC HEALTH RISKS no signs or symptoms of chronic exposure to allyl propyl disulfide have been reported according to the information presently available to the New Jersey Department of Health, allyl propyl disulfide has not been tested for its ability to cause cancer in animals and for its ability to affect reproduction. [Pg.399]

Known active constituents of garlic (there are at least 35 other constituents whose actions are unknown) ajoene, allicin, aliin, allixin, allyl mercaptan, allyl methyl thiosulfmate, allyl methyl trisulfide, allyl propyl disulfide, diallyl disulfide, diallyl hepta sulfide, diallyl hexa sulfide, diallyl penta sulfide, diallyl sulfide, diallyl tetra sulfide, diallyl tri sulfide, dimethyl disulfide, dimethyl trisulfide, dirpopyl disulfide, methyl ajoene, methyl allyl thiosulfmate, propyline sulfide, 2-vinyl-4H-l, 3-tithiin, 3-vinyl-4H-1, 2dithiin, S-allyl cysteine sulfoxide, S-allyl mercapto, cysteine. [Pg.29]

Allyl propyl disulfide (onion oil [CAS 2179-59-1]) Mucous membrane irritant and lacrimator. 2 ppm Liquid with a pungent, irritating odor. A synthetic flavorant and food additive. Thermal-breakdown products include sulfur oxide fumes. [Pg.536]

Europe 0.03 for the related substance diallyl trisulfide and 10 concern USA ND (No. 587) (Morgareidge Oser, 1970b) is Japan 0.08 >4 million times the estimated daily intake of allyl propyl disulfide when used as a flavouring agent. [Pg.193]

For allyl propyl disulfide (No. 1700), the NOEL of 4.6 mg/kg bw per day for the structurally related substance diallyl trisulfide (No. 587) from a 90-day study in rats (Morgareidge Oser, 1970b) provides an adequate margin of safety (>4 million) in relation to currently estimated levels of intake of this substance from use as a flavouring agent. [Pg.215]

Fourteen members of this group of flavouring substances, ethane-1,1 -dithiol (No. 1660), 4-mercapto-2-pentanone (No. 1670), diisopentyl thiomalate (No. 1672), cis- and frans-mercapto-p-menthan-3-one (No. 1673), 2,4,6-trithiaheptane (No. 1684), ( )-2,8-epithio-c/s-p-menthane (No. 1685), mixture of 3,6-diethyl-1,2,4,5-tetrathiane and 3,5-diethyl-1,2,4-trithiolane (No. 1687), ( )-3-(methylthio)heptanal (No. 1692), ethyl methyl disulfide (No. 1693), ethyl propyl trisulfide (No. 1695), methyl isopentyl disulfide (No. 1696), butyl ethyl disulfide (No. 1698), allyl propyl disulfide (No. 1700) and bis(1-mercaptopropyl)sulfide (No. 1709), have assay values of <95%. Information on the safety of the secondary components of these 14 compounds is summarized in Annex 5 (Summary of the safety evaluation of secondary components for flavouring agents with minimum assay values of less than 95%). The secondary component of diisopentyl thiomalate, diisopentyl thiotartronate, is expected to share the same metabolic fate as the primary substance. The secondary components of frans-mercapto-p-menthan-3-one, piperitone (No. 435) and a-terpineol (No. 366), are expected to undergo rapid absorption, distribution, metabolism and excretion and were evaluated at previous... [Pg.217]

Allyl propyl disulfide Reverse mutation" S. typhimurium TM7, TA98, TA100, TA1535 and TA1537 Up to 333 pg/plate Negative Zeigeretal. (1988)... [Pg.228]

Allyl propyl disulfide Reverse mutation S. typhimurium TMOO Not specified Negative Ederetal. (1982)... [Pg.228]

Allyl propyl disulfide Trisulfides Structural class 1 1700 N No safety concern... [Pg.457]

Onion extract. See Onion (Allium cepa) extract Onion oil. See Allyl propyl disulfide Onion (Allium cepa) oil ONP. See o-Nitrophenol ONT. See o-Nitrotoluene Onyx. See Quartz... [Pg.2996]

Propenyl propyl disulfide. See Allyl propyl disulfide... [Pg.3726]

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