Allowable daily intake

No allowable daily intake of atrazine in the human diet has been established, although 0.0375 mg/kg body weight daily has been proposed — equivalent to 2.25 mg daily for a 60-kg adult, or... 

Permissible exposure level (PEL) Occupational Safety and Health Administration Official regulatory Allowable daily intake (ADI) Food and Drug Administration Official regulatory... 

Crump KS (1984) A new method for determining allowable daily intakes. Fundam Appl Toxicol, 4 854-871. 

The Joint FAO/WHO Expert Committee on Food Additives (WHO, 1983) withdrew the previously allocated temporary allowable daily intake (ADI) of 0-0.5 mg/kg body weight and recommended that the use of dichloromethane as an extraction solvent be limited, in order to ensure that its residues in food are as low as practicable. 

ABBREVIATIONS ADI-Allowable daily intake BRL-Bionetics Research Laboratory C EN-Chemical and Engineering News CAS-Chemical Abstracts Service CDC-Center for Disease Control CDD-Chlorodibenzodioxin CDF-Chloradibenzofuran CEQ-Council on Environmental Quality CFR-Code of Federal Regulations CIB-Current Intelligence Bulletin CNS-Central Nervous System d.-Day(s)... 

Substance Typical Levels (ppb) FDA Action Levels for Cow s Milkc Allowable Daily Intake Daily Intake of Breast-Fed Infantd... 

Layton, D.W., Mallon, B J., Rosenblatt, D.H., Small, M J., Deriving allowable daily intakes for systemic toxicants lacking chronic toxicity data. J Reg Tox Pharm, 7(96), 1987. 

K. S. Crump, A New Method for Determining Allowable Daily Intakes, Fundamental and... 

American Conference of Governmental Industrial Hygienists Allowable daily intake... 

This question of whether it is scientifically valid to derive the lifetime control limit by using threshold or non-threshold models defines what cleanup levels are proposed for a site. The action level proposed by CDC for residential soil in Missouri is 1 ppb, based on a series of exposure assumptions and on virtually safe doses for 10"° cancer risk of 0.0276 pg/kg/day (U). If one assumes a different threshold - based model, as did Dutch, Swiss, German, and Canadian workers (9), one obtains maximum allowable daily intake of 1-10 pg/kg/day. If one uses the same exposure calculations as CDC, one could then accept 4-40 ppb in residential soil according to these allowable daily intakes. CDC and ERA have allowed 7 ppb as acceptable residual concentrations at an industrial site in New Jersey (IJ). At Seveso, cleanup levels were set at 45 ppt for nonagricultural soil and 7 ppt for agricultural soil... 

Target levels were established for cleaning equipment surfaces. These levels for normal products were proposed based on a simple evaluation of toxicological data, such as ADI (allowable daily intake) or LD50, and estimates of dermal contact and potential skin adsorption (Table II). 

To establish the subacute toxic threshold value (ADI = allowable daily intake) of Buvinol , Barta-Bedd and Geffert (1976) carried out 90-day feeding tests in male and female albino rats. Mixed with the food, the herbicide was fed at levels of... 

No allowable daily intake of atrazine in the human diet has been established, although 0.0375 mg/kg BW daily has been proposed -equivalent to 2.25 mg daily for a 60-kg adult, or 1.5 mg/kg diet, based on 1.5 kg food daily. In humans, the theoretical maximum residue contribution (TRMC) - a worst case estimate of dietary exposure - is 0.77 mg daily, assuming 1.5 kg of food eaten daily this is equivalent to 0.51 mg/kg diet, or 0.013 mg/kg BW daily for a 60-kg person. Another TRMC calculation is based on 0.233 mg daily per 1.5 kg diet, equivalent to 0.156 mg/kg diet, or 0.0039 mg/kg... 

BW daily for a 60-kg person. Both TRMC estimates are substantially below the proposed limit of 0.0375 mg/kg BW daily. Lifetime exposure to drinking water concentrations of 2.3 (xg atrazine/L poses negligible risk to human health, as judged by the no adverse effect level of 7.5 xg/L when 1% of the allowable daily intake is obtained from this source. Higher allowable concentrations are proposed over short periods 123.0 xg/L for adults and 35.0 jig/L for children, over a 10-day period. The proposed drinking water criterion to protect human health in Western Europe is <0.1 Jig/L. In the United States, it should not exceed 3.0 jig atrazine/L drinking water, although some authorities recommend less than 3.6 jig atrazine/L. 

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