Allergy, screening test

Although they have been successfully applied at the academic level, commercial devices are being developed [548,549]. Impedimetric immunosensors could potentially be used for qualitative purposes, such as, for example, in the detection of bacteria, pregnancy tests, allergy screening tests, etc [546]. 

The RAST Principle and the Use of Mixed-Allergen RAST as a Screening Test for IgE-Mediated Allergies... 

Sousa-Basto A, Azenha A (1994) Textile dye mixes useful screening tests for textile dye allergy. Contact Dermatitis 30 189-190... 

A 4-week, single-blind, randomized, parallel-groups, dose-response study was conducted to test botanicals for allergy as measured by a skin patch test (wheal-and-flare reaction). The study was approved by an independent review board, informed consent was obtained before any screening or study measures, and the study was... 

Inspired by this work (24), we used Bayesian methods (24) with molecular function class fingerprints of maximum diameter 6 (53) to identify substructures that were shown to be important in recent TB screening datasets (21-23). Bayesian models were built with the previously described Molecular Libraries Small Molecule Repository (MLSMR) 220,463 library (4,096 active compounds) (15) and dose-response data using 2,273 molecules (475 active compounds). In addition, these models were tested (15) with the National Institute of Allergy and Infectious Diseases (NIAID) data and GVK Biosciences (Hyderabad, India) datasets used by Prathipati et al. (24). We have validated the models with compounds left out of the original models, in some cases showing up to tenfold enrichments in finding active compounds in the top-ranked 600 molecules (22). 

Prick skin tests are used to screen patients with suspected IgE-mediated food allergies. In Table 3.3.5, there is a list of clinical conditions in which the methods of IgE detection are indicated (Chapman et al., 2006). 

Merthiolate was tested as a matter of routine in an extended standard series of skin tests in patients with different sub-types of eczema and varicose complex (68). Of 880 patients 53% responded positively to one or more allergens, 3.9% to merthiolate. The latest results of skin tests in adults have confirmed the persistence of contact allergy to merthiolate and justify further follow-up and systematic screening. 

Oak moss is a common ingredient in perfumes and is included in the standard fragrance mix used to screen for fragrance allergies (Johansen et al. 2002). Of 59,298 persons that tested positively to fragrance mix between 1996 and 2002,29.9% had reactions to oak moss (Schnuch et al. 2004). In persons with allergic reactions to Frullania, many also tested positive to oak moss (Goncalo 1987). 

Fisher et al. (1971) introduced the vehicle tray in patch testing and thereby increased the physician s awareness of the possibility of contact allergy to vehicle ingredients. The vast majority of vehicles has not been studied in a systematic fashion they have not been subjected to predictive testing in animals and only limited epidemiologic data exist from screening of eczema patients (Hjorth and Trolle Lassen 1963 Hannuksela et al. 1976 a Iden and Schroeter 1977). 

Perfume screening trays for patch testing has been developed to increase the sensitivity and specificity of perf ume allergy detection (Larsen 1977). In 20 perfume-sensitive patients examined with a screening tray of 15 fragrances, jasmin synthetic, cinnamic alcohol, and hydroxycitronellal were the three most common allergens. Rudzki and Grywa (1977 a) tested 35 essential oils and 4 balsams on... 

Decision-support systems, wherein transactions are screened according to a set of rules, add an additional layer of value to transactional systems. To be effective, such systems require that rules be invoked in real time and draw on data relevant to the transaction. For example, a drug order may be contraindicated based on allergies, or a laboratory order may be contraindicated by the results of previous tests or applicability in the context of the patient s condition as recorded in the electronic chart. The implementation of decision-support tectoology requires significant effort in the development of acceptable rules and the processing power to process them in real time. 

Holness DL, Nethercott JR, Adams RM, et al. (1995) Concomitant positive patch test results with standard screening tray in North America 1985-1989. Contact Dermatitis 32 289-292 Karlberg A-T (1988) Contact allergy to colophony. Chemical identifications of allergens, sensitization experiments and clinical experiences. Acta Derm Venereol (Stockh) Suppl 139 1-43... 

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