Skin prick test

The usual diagnostic methods, both skin tests and specific IgE with whole Anisakis extract, have a good sensitivity but a low specificity to such a degree that in 22% of blood donors specific IgE to the parasite is detected [40] and at least 20% of patients with acute urticaria have positive skin prick tests with whole Anisakis extract [41 ]. As for BAT with whole Anisakis extract, Gonzalez-Munoz et al. [42] report a sensitivity of 96% with a specificity of 96%, which are clearly higher values than those from specific IgE. 

Does skin prick test reactivity to purified allergens 64 correlate with clinical severity of peanut allergy ... 

Van der Veen MJ. Mulder M. Witteman AM. van Ree R. Aalberse RC. Jansen HM. van der Zee JS False-positive skin prick test responses to commercially available dog dander extracts caused by contamination with house dust mite (Dermatophagoides pteronyssimus) allergens. J Allergy Clin Immunol 1996 98 1028-1034... 

The further allergologic workup is recommended to be performed between 2 and 6 months after the reaction (table 3) [13]. A skin prick test should be performed with undiluted RCM. Afterwards, IDTs with RCM (300-320 mg/ml) diluted 10-fold in sterile saline and reading after 20 min are recommended [13]. As cross-reactivity is frequent, a panel of several different RCM should be tested in an attempt to find a skin test-negative product, which might be tolerated in future RCM examinations. 

Skin Test. Usually a battery of LAs is tested in the skin-prick test which is almost always negative. Then the intradermal test is performed with a 1 10 dilution of the substances. Undiluted LA preparations may commonly lead to false-positive reactions [30-32] in a rather high percentage of patients. 

In another Spanish study, Crespo et al. (1995) evaluated 355 children on the basis of clinical history, skin prick tests (SPTs), and specific serum IgE to mollusks. Allergies to molluscan shellfish were noted in 10 of these children or 2.8%. However, mollusks caused 1.6% of 608 allergic reactions among this group of children. 

Clearly, some individuals with molluscan shellfish allergy are reactive to all species of molluscan shellfish. Cross-reactivity has been established by clinical history, challenge trials (in a few instances), skin prick testing, and IgE-binding studies. Most clinical studies of cross-reactivity have been limited to a few species often within one class of molluscan shellfish. However, the totality of the evidence indicates that individuals with documented reactivity to one molluscan species and evidence of IgE against that species should be counseled to avoid other molluscan shellfish species. This recommendation is especially prudent for the individual classes of molluscan shellfish gastropods, bivalves, and cephalopods. 

Allergenic effect. A food industry worker developed asthma in inhalation of dust from spices. Skin prick test from ginger was strongly positive. With radioallergosorbent... 

HDI exposure has also been reported to induce the production of immunoglobulins, mainly IgG and IgE (Belin et al. 1981 Grammar et al. 1988, 1990 Patterson et al. 1990), making this response a potential for use as a biomarker of exposure. Several difficulties arise when attempting to use blood immimoglobulin levels specifically as an HDI biomarker of exposme. As discussed earlier, there is no one specific test to detect the antibodies produced exclusively in response to HDI exposure. Cross-reactivity does occur with the HDI-HSA antigen and other aromatic isocyanates, such as TDI and MDI (Belin et al. 1981), making serum or skin antibody measmements of limited value as a biomarker of HDI exposure when workers may have been exposed to more than one diisocyanate. The presence and quantity of antibodies found in the serum or after RAST and skin prick tests do not always correlate to the occurrence of ocular, nasal. 

Skin prick tests were positive for isolated paramethasone in both patients, but negative for mepivacaine. There has only been one previous report of anaphylaxis in association with paramethasone. 

An asthmatic patient using inhaled budesonide and salbutamol developed an acute asthma attack. Despite emergency treatment the patient deteriorated, requiring endotracheal intubation and assisted ventilation, and there was no improvement until the glucocorticoid was withdrawn, after which there was steady improvement. Skin prick tests with prednisolone, sodium hemisuccinate, and 6-methylprednisolone-sodium hemisuccinate were positive. Thirty minutes after intradermal 6-methylprednisolone-sodium hemisuccinate 4 mg, the patient developed a dry cough, dyspnea, and wheezing and a 17% fall in FEVi. 

A 5-year-old child with diabetes, Pierre Robin syndrome, cleft palate, allergic rhinitis, recurrent sinusitis, and obstructive sleep apnea, who had previously had skin rashes after penicillin, sulfonamides, and clindamycin, was given soluble and isophane human insulins (131). Three years later she developed local reactions, 2-5 cm areas, 30-120 minutes after injection. Skin-prick tests were negative for the diluent, isophane, and soluble insulin, but intradermal testing was positive with both insulins. Cetirizine and dexamethasone added to the insulin gave temporary relief. She was... 

A 45-year-old man with type 2 diabetes treated with glibenclamide and metformin received combined chemotherapy for non-Hodgkin s lymphoma and was given premixed insulin. He developed local wheal-and-flare reactions immediately after the injections. Skin prick tests were positive for various types of insulin but weakly positive for lispro and negative for insulin aspart. He tolerated aspart insulin without any allergic reactions. 

The signs and symptoms considered were rhinorrhea, nasal obstruction and sneezing. The morphological structure of the nasal cavities was examined with anterior rhinoscopy. Skin prick tests, nasal provocation tests, nasal microbiological tests and mucociliary clearance time (MCT) were used to identify the causal factors. The skin prick tests were used to... 

Patients were ineligible if they had skin prick tests or nasal provocation tests positive to more than one allergen significant diseases or malformations of the nasal cavities such as nasal polyposis, septal deviation, choanal atresia nasal swab positive for bacteria or mycetes, or immunotherapy in the preceding 5 years. 

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