Allergic hemolysis

In some drug reactions, several of these hypersensitivity responses may present simultaneously. Some adverse reactions to drugs may be mistakenly classified as allergic or immune when they are actually genetic deficiency states or are idiosyncratic and not mediated by immune mechanisms (eg, hemolysis due to primaquine in glucose-6-phosphate dehydrogenase deficiency, or aplastic anemia caused by chloramphenicol). 

Cinnamomum cassia, a species of cinnamon related to that found in Herbal Blend, inhibits complement-dependent allergic reaction by reducing immunological hemolysis, chemotactic migration of neutrophils, and the generation of chemotactic factors by mast cells in response to complement-activated serum.9... 

Crossover studies have shown that mesalazine has about a 10-fold lower potential than sulfasalazine for inducing allergic reactions or causing intolerance. Adverse effects with all aminosalicylates include (generally more frequent with sulfasalazine) headache, nausea, abdominal pain, dyspepsia, fatigue, rash, fever, rarely exacerbation of the disease, pancreatitis, pericarditis, pneumonitis, liver disease, nephritis, and bone marrow depression. Watery diarrhea is an adverse effect unique to olsalazine, while anorexia, folate malabsorption, hemolysis, neutropenia, agranulocytosis, male infertility, and neuropathy are unique to sulfasalazine. 

Renal damage accompanies acute hemolysis due to quinine. Renal insufficiency in cases of quinine poisoning is probably due to circulatory collapse. Allergic reactions underlie at least some cases. The picture can be complex, with the renal insufficiency coming in association with cortical necrosis, thrombocytopenia, intravascular coagulation, and deposition of fibrin. 

In an open trial in 25 patients treated with sulfamethoxy-pyridazine (1 g/day) for mucous membrane pemphigoid unresponsive to topical steroid treatment, 12% of patients were withdrawn, 4% because of allergic reactions, the others because of significant hemolysis (6). 

Hypersensitivity reactions (2% incidence) wide range, but rashes and drug fever most common, positive Coombs test, but rarely hemolysis. Assume complete cross-allergenicity between individual cephalosporins and partial cross-hypersensitivity with penicillins (about 5%). Most authorities recommend voiding (iTffl S()[ >1.cephalosporins in patients allergic to penicillins (tor gram-positive organism ... 

Patients with a history of a mild or a temporally distant penicillin reaction appear to be at low risk of allergic reaction following cephalosporin administration. However, patients who have had a recent severe, immediate reaction to a penicillin should be given a cephalosporin with great caution, if at all. A positive Coombs reaction appears frequently in patients who receive large doses of a cephalosporin, but hemolysis is rare. Cephalosporins rarely have produced bone marrow depression characterized by granulocytopenia. 

HEALTH SYMPTOMS inhalation (sore throat, coughing, labored breath, dizziness, bluish skin, faintness) skin contact (dry skin, redness, pain, may cause allergic skin reaction) skin absorption (symptoms parallel those toxic effects noted for inhalation and ingestion) eye contact (redness, pain, destructive to eye tissue) ingestion (nausea, vomiting, diarrhea, abdominal pain, weakness, vertigo, jaundice, hemolysis of red blood cells). 

It can be seen that 23 patients were reported as experiencing some type of allergic reaction, but it is likely that fever, hemolysis, and certain of the hepatic effects may also have an immunological basis. 

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