Herbal blend

The Herbal Blend, composed of equal parts by weight of cinnamon bark extract (Cinnamomum zeylanicum), acerola fruit (Malpighia glabra), and Spanish needles powder (Bidens pilosa), was one of the first combination formulas assayed. Surprisingly, it showed synergistic inhibition of histamine release The sum of the inhibition of the three ingredients was 10.2% of control, whereas their combination inhibited histamine release to -52% (i.e., to below the concentration of histamine found in unstimulated cells). 

A series of bioassays was utilized to screen a variety of single and combination botanical compounds for anti-allergy action in vitro. A combination of three ingredients—Herbal Blend—showed apparent synergistic inhibition of histamine. However, in vitro efficacy against allergic mediators does not ensure effectiveness in native disease—that is, in allergy sufferers in daily life. In addition, the commercial... 

Herbal blend (equal-weight 90 mg/dose in 135 mg/dose in 180 mg dose in... 

Data in Table 10.4 are shown as unadjusted allergen response data (that is, without reference to the saline condition) because of inconsistent response to histamine as the positive control, and large baseline between- and within-groups variability. Results for Herbal Blend showed a trend toward a dose-response effect (Figure 10.2). No significant adverse experiences were reported and results of serum chemistries, hematology, and urinalysis were not statistically different before and after treatment from all groups. 

Figure 10.2 Wheal size change by Herbal Blend dose (means of replicate experiments SEM).

Twenty subjects (nine men and 11 women) with a mean age of 38 years took part in this study. Of those subjects, 17 completed all treatments (placebo, loratadine, and Herbal Blend) three subjects who were unable to attend all test sessions were excluded from pair-wise analyses on a per-comparison basis. The demographic variables for subjects in this study are listed in Table 10.5. 

During the NAC, loratadine was associated with significantly fewer symptoms than placebo at the highest dose of allergen (6250 AUs) (P = 0.04, t = 1.83, df = 19) as well as overall, expressed as the sum of nasal symptom scores experienced over the NAC (P = 0.04, t = 1.83, df = 19). During the NAC, there were no statistically significant differences between Herbal Blend and placebo at any time point (Figure 10.3). 

Figure 10.4 Nasal symptom scores during late-phase response. = P = 0.04 for Herbal Blend and placebo areas over NSS curves = P = 0.007 Herbal Blend versus placebo at 6 h.

Analysis of NSS areas over the curve, a clinically relevant measure of total product effect over the 8-hour period following the NAC, showed that loratadine and Herbal Blend were not significantly different from each other (P = 0.28, t = -0.6, df= 16) and that both were significantly better than placebo (P = 0.03, t = 1.96, df = 17 for loratadine, and P = 0.03, t = 2.04, df = 16 for Herbal Blend) (Figure 10.5). 

Figure 10.6 Objective sneeze counts during late phase (2-8 h after nasal challenge). and = P < 0.10 and 0.05, respectively, Herbal Blend versus placebo.

Cinnamomum cassia, a species of cinnamon related to that found in Herbal Blend, inhibits complement-dependent allergic reaction by reducing immunological hemolysis, chemotactic migration of neutrophils, and the generation of chemotactic factors by mast cells in response to complement-activated serum.9... 

Marks LS, Partin AW, Epstein JI, et al. Effects of saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000 163 1451-1456. 

Peppermint oil is obtained from flowering tops and leaves of Menta x piperita L. (herbaceous perennial plant, Lamiaceae), yield of 0.3-0.7%. The oil is a colorless, pale yellow or pale greenish-yellow liquid. It has a characteristic mint odor and taste followed by the sensation of cold. It is used to give a peppermint flavor to a wide range of applications, at first as flavor additives in bubble gum and toothpaste. It is also used in mint and herbal blends and in liquor and sweets flavors. 

Cornmint oil is obtained from flowering tops and leaves of Mentha canadensis L. (M. arvensis L., Japanese mint, Lamiaceae), yield of 0.5-2%. The content of menthol achieved 90% of the oil. Menthol is partly separated by crystallization and the remaining oil has appearance and odor resembling peppermint oil. The oil is used as a cheap alternative to peppermint oil, but easily recognized organoleptically because of its harsh flavor. Commint oil can be used in herbal blends and liquor flavors. Menthol obtained from the oil is mainly used in dmg and cigarette production. 

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