Allergenic dermatitis

Scheuer E, Warshaw E. Sunscreen allergy A review of epidemiology, clinical characteristics, and responsible allergens. Dermatitis 2006 17(1) 3 11. 

Hazard The toxic principle of poison ivy. Causes severe allergenic dermatitis. 

Balsam Peru is one of the most common contact allergens. Dermatitis as a result of contact with this balsam is documented in many countries.A double-blind, placebo-controlled study found that taken orally, balsam of Peru caused allergic dermatitis to flare. ... 

Andersen KE, White IR, Goossens A Allergens from the standard series in Frosch PJ. Menne T. Lepoittevin JP (eds) Contact Dermatitis. Heidelberg, Springer, 2006, pp 453-492. 

Irritant contact dermatitis results from first-time exposures to irritating substances such as soaps, plants, cleaning solutions, or solvents. Allergic contact dermatitis occurs after an initial sensitivity and further exposure to allergenic substances, including poison ivy, latex, and certain types of metals. 

Marks JG Jr, Belsito DV, DeLeo VA, Fowler JF Jr, Fransway AF, Maibach HI, Mathias CG, Pratt MD, Rietschel RL, Sherertz EF, Storrs FJ, Taylor JS North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. J Am Acad Dermatol 1998 38 911— 918. 

The most frequent causes of allergic contact dermatitis in the United States include plants (poison ivy, poison oak, and poison sumac), metallic salts, organic dyes, plastic resins, rubber additives, and germicides.74 The most common skin patch test allergens found to be positive in patients along with potential sources of exposure are shown in Table 32.1.75 In patients with occupational contact dermatitis who were skin patch tested, the common allergens included carba mix, thiuram mix, formaldehyde, epoxy resin, and nickel.76... 

Bodin, A., et al., Identification and allergenic activity of hydroxyaldehydes — anew type of oxidation product from an ethoxylated non-ionic surfactant, Contact Dermatitis, 44, 207, 2001. 

Kligman, A.M., The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J. Invest. Dermatol., Al, 375, 1966. 

Basketter, D.A., et al., Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Dermatitis, 42, 344, 2000. 

Gerberick, G.F., et al., Contact allergenic potency correlation of human and local lymph node assay data. Am. J. Contact Dermat., 12, 156, 2001. 

Atopic dermatitis has been proposed to be the cutaneous manifestation of IgE-mediated hypersensitive reaction to allergenic substances [29]. Conceptually, antagonizing IgE emerges as a logical therapeutic option. Systemic treatment with omalizumab, however, appears to be less efficacious in the skin than in the airway mucosa [23]. It is possible that small molecule Syk inhibitors may offer a more suitable mode to reach and prevent activation of sensitized dermal mast cells and dendritic cells. 

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