Local lymph node assays

Reduced local lymph node assay (rLLNA) for skin sensitization EU, US... 

Kimber, I. and Weisenberger, C., A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study, Arch. Toxicol., 63, 274, 1989. 

Kimber, I. et al., The local lymph node assay past, present and future, Contact Dermatitis, 47, 315, 2002. 

Sailstad, D.M. et al., ICCVAM evaluation of the murine local lymph node assay. I. The ICCVAM review process, Regul. Toxicol. Pharmacol., 34, 249, 2001. 

OECD Guideline for the Testing of Chemicals 429 Skin Sensitisation Local Lymph Node Assay. Adopted April 24, 2002). 

The most important advance in ACD testing has been the development of the murine local lymph node assay (LLNA). Although the general concept originated in the 1960s,... 

Kimber, I., Hilton, J. and Botam, P. A., Identification of contact allergens using the murine local lymph node assay comparison with the Buehler occluded patch test in guinea pigs, J. ofAppl. Toxicol., 10, 173, 1990. 

Finally, multiparameter flow cytometry has the potential to improve existing methodologies for the evaluation of immunotoxicological endpoints such as the natural killer cell (NK) assay and the local lymph node assay (LLNA) to evaluate innate immunity and chemical-induced allergic disease. Accepted methodologies typically utilize radio-... 

Kanikkannan, N., et al., Evaluation of skin sensitization potential of jet fuels by murine local lymph node assay, Toxicol. Lett., 116, 165, 2000. 

NIEHS, Interagency Coordinating Committee for Validation of Alternative Methods (IC-CVAM) Peer Review Panel Evaluation of the Murine Local Lymph Node Assay (LLNA) Report, 1999. 

Basketter, D.A., Gerberick, G.F., and Kimber, I., Skin sensitisation, vehicle effects and, the local lymph node assay. Food Chem. Toxicol., 39, 621, 2001. 

Warbrick, E.V., et al., Influence of application vehicle on skin sensitization to methylchlo-rothiazolinone/isothiazolinone An analysis using the local lymph node assay. Contact Dermatitis, 41, 325, 1999. 

Wright, Z.M., et al., Vehicle effects on the skin sensitizing potency of four chemicals assessment using the local lymph node assay. Ini. J. Cosmetic Sci., 23, 75. 

Basketter, D.A., et al., Use of the local lymph node assay for the estimation of relative contact allergenic potency. Contact Dermatitis, 42, 344, 2000. 

Gerberick, G.F., et al., Contact allergenic potency correlation of human and local lymph node assay data. Am. J. Contact Dermat., 12, 156, 2001. 

Kimber, I. and Basketter D.A., The murine local lymph node assay A commentary on collaborative studies and new directions. Fd. Chem. Toxicol., 30, 165, 1992. 

OECD Guidelines for Testing Chemicals. Guideline 429. Skin Sensitization Local Lymph Node Assay, 2002. 

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