Allergen extracts

Additional miscellaneous proteins Gene therapy products Allergenic extracts... 

Gustafsson MG, Hammerhng U Multivariate statistical analysis of large-scale IgE antibody measure- 27 ments reveals allergen extract relationships in sensitized individuals. J Allergy Clin Immunol 2007 120 1433-1440. 28... 

In allergen immunotherapy, specific allergen extracts (also called allergen vaccines) are administered in order to modify or eliminate allergic rhinitis symptoms. 

DAmato, and G. DAmato. Evaluation of serum specific IgE and skin responsiveness to allergenic extracts of Oleaceae pollens (Olea europaea, Frax-inus excelsior and Ugustrum vulgare) in patients with respiratory allergy. Allergol Immunopathol (Madr) 1995 23(1) 41-46. 

OE231 Casanovas, M., E. Guerra, C. Moreno, R. Miguel, E. Maranon, andj. C. Daza. Double-blind, placebo-controlled clinical trial of preseasonal treatment with allergenic extracts of Olea europaea pollen administered sublingually. J Investig Allergol Clin Immunol 1994 4(6) 305-314. 

FDA Guidance for Industry on the Content and Format of Chemistry, Manufacturing, and Controls and Establishment Description Information for Allergenic Extract or Allergen Patch Test (April 1999)... 

Clinical tolerance to allergens may be achieved by the administration of allergen extracts, which is called specific immunotherapy. In addition to its therapeutic value, it has been suggested that this treatment may also alter the progression of disease. Specific allergen immunotherapy (SIT) is used to alleviate the condition associated... 

Feliziani Y Lattuada G, Parmiani S, Dall Aglio PP Safety and efficacy of sublingual rush immunotherapy with grass allergen extracts A double-blind study. Allergol Immunopathol 1995 23/5 224-230. 

Fig. 4. Individual reactions of the bronchial system measured by body plethysmography in 4 patients given the same amount of allergen extract (0.5 ml Botrytis cinerea) [15]. 

Luderitz-Puchel U, Keller-Stanislawski B, Haustein D Risk reevaluation of diagnostic and therapeutic allergen extracts. An analysis of adverse drug reactions from 1991 to 2000. Bundes-gesundheitsbl Gesundheitsforsch Gesundheitsschutz 2001 44 709-718. 

Feliziani Y Marfisi RM, Parmiani S Rush immunotherapy with sublingual administration of grass allergen extract. Allergol Immunopathol (Madr) 1993 21/5 173-178. 

Calcium phosphate allergenic extract (Stallergenes) maintenance 0.15-0.75ml of 10 IR/ml at 2 weeks intervals for 3-6 months and then at 4 weeks intervals cumulative doses 131 IR content of major allergens no data Guez et al. [9]... 

An intriguing question concerns the immune response elicited by allergen extracts at the mucosal surface. Some studies, in animal models, provided interesting information the dendritic cells of oral mucosa act as efficient antigen-presenting cells and produce IL-12, which directs the immune response towards a Thl profile away from pro-IgE-Th2 profile [6-8],... 

Mueller RS, Bettenay SV Evaluation of the safety of an abbreviated course of injections of allergen extracts for the treatment of dogs with atopic dermatitis. Am J Vet Res 2001 62 307-310. 

As mentioned before, LNIT requires a particular administration technique after premedication, the allergenic extract (aqueous or powdered) has to be sprayed into a nostril while vocalizing. This fact, in addition to the efficacy limited to the nose, reduced the clinical use of LNIT therefore, no postmarketing surveillance studies are available. In conclusion, based on the clinical trials, LNIT appears safe and well tolerated. The EAACI/ESPACI position paper states that side effects do not represent a problem [12],... 

Kahler H, Stuwe H, Cromwell O, Fiebig H Reactivity of T cells with grass pollen allergen extract and allergoid. Int Arch Allergy Immunol 1999 120 146-157. 

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