Plethysmography, body

Using animal models, whole body plethysmography has been used to assess both early and late phase airway responses in guinea pigs, rats and mice [2,28-32], However,... 

Most lung volumes can be measured with a spirometer except total lung capacity (TLC), functional residual capacity (FRC) and residual volume (RV). The FRC can be measured by helium dilution or body plethysmography. 

Fig. 4. Individual reactions of the bronchial system measured by body plethysmography in 4 patients given the same amount of allergen extract (0.5 ml Botrytis cinerea) [15]. 

Whole body plethysmography (Buxco , EMKA Technologies, Paris). (Fig. 1). 

Airway responsiveness is measured by recording respiratory pressure curves by whole body plethysmography in response to inhaled methacholine, for 20 s, using the XA 157 program. The data are analyzed using Excel or datanalyst software (see Fig. 1) (12). 

Whole body plethysmography apparatus (Buxco, Hartford, CN). 

Increased static lung volumes (FRC and TLC), as assessed by whole-body plethysmography, are also a diagnostic feature of asthma (Fig. 9). This is presumably due to premature closing of the airways during expiration be-... 

Although PFTs can provide important information about a patient s condition, the limitations of these tests must be considered. First, they are nonspecific in that they cannot determine which portion of the lungs is diseased, only that the disease is present. Second, PFTs must be considered along with the medical history, physical examination, x-ray examination, and other diagnostic procedures to permit a complete evaluation. Finally, the major drawback of some PFTs is that they require a full patient cooperation and for this reason these tests cannot be conducted on critically ill patients. Consider some of the most widely used PFTs spirometry, body plethysmography, and diffusing capacity. 

Leigh, D.E., and Mead, ]., Principles of body plethysmography. National Heart and Lung Institute, Bethesda, MD NH, 1974. 

American Associatiim for Respiratory Care, 1994, Clinical Practice Guideline Body Plethysmography, Respir. Core, 39(12) 1184-1190,... 

Although the whole-body plethysmography for unrestrained animals is the most widely used method to assess the respiratory risk of new drugs in safety pharmacology, non-appropriate experimental conditions may mask deleterious side effects... 

As an indirect measurement of changes in airway resistance, unrestrained whole-body plethysmography (WBP) has been developed to measure airway reactivity in conscious animals (Lomask 2006). A nondimensional parameter based on a characteristic change in the expiratory waveform of the WBP signal, termed Penh (enhanced Pause), has been used as an indicator of bronchoconstriction. The calculation of Penh is ... 

Respiration rate, inspiratory and expiratory times, tidal volume, minute volume, peak inspiratory and expiratory flows Whole-body plethysmography Rat mouse... 

Typically, respiratory system SP assessments of SMs are performed using either head-out or whole-body plethysmography. Parameters such as respiratory rate (RR) and tidal volume (TV) are measured, and many other parameters such as minute volume, peak inspiratory flow (PIF), peak expiratory flow (PEF), enhanced pause (Penh), inspiration time (IT), and expiration time (ET) are derived. Although there are many methods for respiratory function assessment in rodents (Murphy 2002, 2014 Hoffman et al. 2007 Hoymann 2012), such methods have not been validated extensively for large animals such as NHPs. Therefore, respiratory... 

Chest radiograph, thoracic CT and lung function with body plethysmography are important to assess the size of donor and recipient lungs, one of the most important criteria for defining the matching donor. 

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