Specific allergen immunotherapy

Larche M. Akdis CA. Valenta R Immunological 6 mechanisms of allergen-specific immunotherapy. 

Mechanisms of allergen-specific immunotherapy l20 T-regulatory cells and more. Immunol Allergy Chn North Am 2006 26 207-231. 

Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol 2005 116 608-613. 

Carter MC, Uzzaman A, Scott LM, et al Pediatric mastocytosis routine anesthetic management for a complex disease. Anesth Analg 2008 107 422-427. Bonadonna R Zanotti R, Caruso B, et al Allergen-specific immunotherapy is safe and effective in patients with systemic mastocytosis and Hymenoptera allergy. J Allergy Clin Immunol 2008 121 256-257. 

While in anaphylaxis caused by other frequent elicitors like food and drugs, allergen-specific immunotherapy is not established, immimotherapy with Hymenoptera venoms has been shown to be effective in three prospective controlled trials (table 4) [38-40] and also in a number of studies where patients were submitted to a sting challenge with the responsible insect during venom immimotherapy (table 5) [44]. While over 90% of vespid venom-allergic patients are fully protected and do not develop any... 

If possible, refer patient to allergen-specific immunotherapy (e.g. insect venom anaphylaxis)... 

Bussmann C, Bockenhoff A, Henke H, Werfel T, Novak N Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis J Allergy Chn Immunol 2006 118 1292-1298. 

Peripheral T-Cell Tolerance in Allergen-Specific Immunotherapy... 

Ebner C Immunological mechanisms operative in allergen-specific immunotherapy. Int Arch Allergy Immunol 1999 119 1-5. 

Akdis CA, Blaser K Mechanisms of allergen-specific immunotherapy. Allergy 2000 55 522-530. 

While on the one hand the aspects of Tregs and tolerance induction in allergen-specific immunotherapy and different procedures of vaccination are described, one chapter is added which describes future possibilities of stem cell transplantation in genetically linked disorders. 

Griffin CE, Hillier A The ACVD task force on canine atopic dermatitis Allergen-specific immunotherapy. Vet Immunol Immunopathol 2001 81 363-383. 

Allergen-specific immunotherapy (IT) is the practice of administering increasing amounts of allergens to allergic subjects in order to achieve a hyposensitization and to reduce the symptoms during the natural exposure to the... 

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