Other Allergenic Extractives

The disease known as hot-tub dermatitis can be caused by bathing in redwood Sequoia sp.) tubs. The disease is caused by a bacterium Pseudomonas sp.) that enters via hair follicles (180), and it is probably not related in any causal way to the use of redwood. 

Maple-bark disease was described as a pulmonary hypersensitivity to Cryptostroma corticate (152). Yellow poplar Liriodendron tulipifera) wood caused a severe contact dermatitis (168, 190). 

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Proteins were then dissolved in 20 mL of 0.125 M Tris-HCl, pH 7.4 containing 1% (m/v) CHAPS and the protease inhibitor cocktail, and treated with CPLL. With several variations from the standard treatments such as other complementary extractions from seeds, the use of urea-containing extraction buffer, and an additional peptide ligand library, the total number of detected gene products was quite large. Two hundred and thirty one unique proteins were found in the pulp (vs. 56 described previously) and 61 in the seeds (vs. only four reported by the literature). In the latter case, the presence of seed storage proteins, oleosins, and histones were detected in the pulp, a thaumatin-like protein, an allergenic protein also named Ole el3, was confirmed. 

Only three well-documented studies have addressed cross-reactivity among or involving basidiomycetes [46,58,61]. These studies all used allergen extracts to inhibit IgE-specific immunochemical assays. RAST inhibition was first used to detect the cross-reactivity of various basidiospore allergen extracts [61]. The second study included spores from six different mushrooms, and the results were concordant with the taxonomic classification of basidiomycetes. Four species from related orders (C. quadrifidus, C. cyathiformis, P. ostreatus, P cubensis) were significantly cross-reactive species from two unrelated orders Ganoderma meredithae, Pleurotus tinctorinus) showed only minimal cross-reactivity with one another or the other four species [58]. 

Small-volume injectables can be therapeutic injections, ophthalmics, diagnostics, radiopharmaceuticals, or allergenic extracts. The active ingredients can be intended for human or animal therapy and can be small molecules, proteins and other large molecules, biologies, vaccines, monoclonal antibodies, antisense oligonucleotides, and, in the future, genes. 

Walls AF, Longbottom JL (1983) Quantitative immunoelec- 214. trophoretic analysis of rat allergen extracts. I Antigenic characterization of fur, urine, saliva and other rat-derived materials. Allergy 38 419-431... 

Walls AF, Longbottom JL (1985) Comparison of rat fur, 216. urine, salive, and other rat allergen extracts by skin testing,... 

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