Alkylbenzyldimethylammonium chloride

The most widely used preservative remains benzalkonium chloride, which often is supplemented with disodium edetate. The benzalkonium chloride defined in the USP monograph is the quaternary ammonium compound alkylbenzyldimethylammonium chloride, in which the alkyl portion is composed of a mixture of chain lengths ranging from C8 to C16. This compound s popularity is based, despite its compatibility limitations, on its being the most effective and rapid-acting preservative with excellent chemical stability. It is stable over a wide pH range and does not... 

Alkylbenzene sulfonic acid, quahty optimization of, 23 552 Alkyl (C12-C15) benzoate, 3 635 Alkylbenzyldimethylammonium chlorides, 2 21... 

Fig. 2.1.9. Mass chromatograms (m/z 58) of alkylbenzyldimethylammonium chlorides as their corresponding alkyldimethylamines and the internal standard (undecyldimethyl-amine) (a) prior to debenzylation and (b) after Hofmann degradation with potassium tert-butoxide and El mass spectra detected in river water. Reproduced with permission from Ref. [141]. 2001 by American Chemical Society.

A mixture of alkylbenzyldimethylammonium chlorides of the general formula [C6H5-CH2 N(CH3)2 R]C1, in which R represents a mixture of the alkyls from CsHi7 to C18H37. CAS—8001-54-5... 

Alkylbenzyldimethylammonium chloride alkyl dimethyl benzyl ammonium chloride BKC Hyamine 3S00 Pentonium Zephiran. 

Benzalkonium chloride is a mixture of alkylbenzyldimethylammonium chlorides of the general formula [CgH5CH2N(CH3)2R]Cl, where R represents a mixture of the alkyls from C8Hi7 to C18H37. In dilute solution (1 in 1000 to 1 in 2000) it may be used for the preoperative disinfection of skin and mucous membranes, for application to burns and wounds, and for cleaning polythene and nylon tubing and catheters. Benzalkonium chloride is also used as a preservative for eye-drops and as a permitted vehicle for the preparation of certain eye-drops. 

A, air H, water W, waste Al, aliphatic amine AA, aromatic amine PAA, polyaromatic amine ABDAC, alkylbenzyldimethylammonium chloride AME, alkylamine ethoxylates T, tertiary amine PE, polyethylene PS/DVB, polystyrene/divinylbenzene PDMS, polydimethylsiloxane PA, polyacrylate PAB, polyacrilonitrilbutadiene. 

HA, heterocyclic amine AA, aromatic amine PA, polyamine Al, aliphatic amine N, nitrosamine MAM, Musk amino metabolities ABDACs, alkylbenzyldimethylammonium chlorides BCD, electron capture detection AED, atomic emission detection FID, flame ionization detection FPD, flame photometric detection GC-MS-SIM, GC-MS selected ion monitoring NPD, nitrogen phosphorus detection NlCl, negative-ion chemical ionization El, electron ionization CGC, capihary GC A, air H, water W, waste. 

HA, heterocyclic amine AA, aromatic amine Al, aliphatic amine ABDACs, alkylbenzyldimethylammonium chlorides. 

Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl chlorides. See Quaternium-18 Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl, chlorides, reaction prods, with bentonite. See Quaternium-18 bentonite Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl, chlorides, reaction prods, with hectorite. See Quaternium-18 hectorite Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl, compds. with bentonite and C8-C18-alkylbenzyldimethylammonium chloride. See Quaternium-18/benzalkonium bentonite Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl, methyl sulfates. See Quaternium-18 methosulfate Quaternary ammonium compds., bis (hydroxyethyl) methyltallow alkyl, chlorides. See PEG-2 tallowmonium chloride Quaternary ammonium compds.. Cl 2-18-alkyl (hydroxyethyl) dimethyl, chlorides. See Alkyl dimethyl hydroxyethyl ammonium chloride Quaternary ammonium compds., C14-18 alkyl trimethyl, bromides. See Alkyl trimethyl ammonium bromide... 

Quaternium-18/benzalkonium bentonite Synonyms Quaternary ammonium compds., bis (hydrogenated tallow alkyl) dimethyl, compds. with bentonite and C8-C18-alkylbenzyldimethylammonium chloride Definition Reaction prod, of bentonite, quaternium-18, and benzalkonium chloride Uses Vise, control agent, gellant in cosmetics thixotrope for paints... 

Synonyms N-hexadecyl-N,N-dimethyl-benzenemethanaminium chloride benzyldimethylhexadecylammonium chloride monohydrate Cetalkonium chloride monohydrate Cetol monohydrate N-hexadecyl-N,N-dimethylbenzenemethanaminium chloride monohydrate benzyl hexadecyl dimethyl ammonium chloride Ci6-alkylbenzyldimethylammonium chloride hexadecyl dimethyl benzyl ammonium chloride benzyl-n-hexadecyl dimethylammonium chloride monohydrate... 

Benzalkcmium chloride is available as Benzalkonium Chloride Solution (Ph. Eur.) which contains a mixture of alkylbenzyldimethylammonium chlorides in water at a concentration of 500 g/L (50 % w/v). If the final concentration of benzalkonium chloride in a product has to be 0.01 % (either w/v or w/w), for 1,000 mL of the preparation 100 mg of benzalkonium chloride is required. Volume measuring would require 0.2 mL of the Benzalkonium Chloride Solution (50 % w/v) to be taken which cannot be performed with adequate accuracy because of its high viscosity. For weighing instead, the density of the solution has to be known. Density may be taken from the product certificate issued by the manufacturer or it has to be measured. If the density would be 0.9805 g/mL (as measured) one should weigh 196 mg of the 50 % Benzalkonium Chloride Solution for 1,000 mL of the solution to be prepared. 

The disinfection efficacy of quats depends on the length of the aliphatic residue attached to the quaternary nitrogen. In a smdy comparing the activity of homologous series of alkylbenzyldimethylammonium chlorides. Cutler et al. [4] determined that the optimal bacteridical activity waa foimd for C12-C14 alkyl chains. Reybrouck (personal communication) has shown that maximum benzalkonium chloride bactericidal activity is found with the Ci4 alkyl chain compound. 

Figure 6.40 Composite diagram showing primary phase boundaries between sodium cromoglycate and an homologous series of alkylbenzyldimethylammonium chlorides at 25°C. The diagram for the C14 compound is shown with details of the phases observed.

AlkylBDMAC = = Alkylbenzyldimethylammonium chloride. ClBz = chlorobenzene. Total surfactant concentration = 3... 

Nakae, A., K. Kunihiro, G. Muto, Homologous alkylbenzyldimethylammonium chlorides and alkylpyridinium halides by HPLC,X Chromatogr., 1977,134,459-466. 

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