Alkylating substance

B2) 888 (Aj) methyl groups in transposition assignment acc. to local symmetry C21,. Compounds with higher alkyl substance are known, too (43)... [Pg.72]

Clara M, Scheffknecht C, Scharf S, Weiss S, Cans O (2008) Emissions of perfluorinated alkylated substances (PFAS) from point sources - identification of relevant branches. Water Sci Technol 58 59-66... [Pg.40]

Positive-negative-ion chemical ionization mass spectrometry enables the detection of harmful compounds because of their reaction with alkylating substances (29-30). [Pg.67]

Aziridines can be detected by a color reaction with 4-(4 -nitrobenzyl)pyridine that was originally developed for the detection and/or determination of a wide range of alkylating substances. 58 It can be adapted to TLC. 59 60 Upon acid hydrolysis of aziridine-2-carboxylic acid containing peptides, as required for amino acid analysis, this amino acid is recovered as serine in varying yields. 47 Configurational characterization of aziridine-2-carboxylates is performed by NMR spectroscopy 47 51 61-63 and X-ray analysis. 61 In addition, optical rotation of the related benzyl Wtritylaziridine-2-carboxylate is also used 64 with [a]D —95.5 (c 1, THF) for the 25-enantiomer 44 as reference. [Pg.56]

Dacarbazine (DTIC-Dome) is metabolized to an active alkylating substance. It is used in the treatment of malignant melanoma and causes myelosuppression. [Pg.113]

LC-MS/MS is recognized as the technique of choice for analysing many environmental pollutants, for example fluorinated alkyl substances (FASs). These organic compounds contain carbon and fluorine, and arise as a result of biological and geochemical processes, and may be produced synthetically for heat-, oil- and water-resistant products. FAS contaminants have been identihed in environmental and biological samples, and can bioaccumulate to toxic levels. LC-MS/MS has been widely used to study FAS contaminants in water, sediment and biological samples, and may confirm and extend more limited LC-MS studies. [Pg.196]

Villagrasa, M., Lopez de Alda, M., Barcelo, D. Environmental analysis of fluorinated alkyl substances by liquid chromatography-(tandem) mass spectrometry a review. Anal. Bioanal. Chem., 386 953-972 (2006). [Pg.62]

Jahnke, A., Ahrens, L., Ebinghaus, R., Berger, U., Barber, J. L., Temme, C. An improved method for the analysis of volatile polyfluorinated alkyl substances in environmental air samples. Anal. Bioanal. Chem., 387 965-975 (2007). [Pg.63]

Verreault, J., Berger, U., Gabrielsen, G. W. Trend of perfluorinated alkyl substances in herring gull eggs from two coastal colonies in northern Norway 1983-2003. Environ. Sci. Technol, 41 6671-6677 (2007). [Pg.69]

Barber, J., Berger, U., Chaemfa, C., Huber, S., Jahnke, A., Temme, C., Jones, K. C. (2007) Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe. J. Environ. Monit., 9 530-541. [Pg.235]

The gene mutation inhibits hydrolytic cleavage of fumarylacetoacetate into fumarate and acetoacetate. Consequently, the toxic precursors maleylacetoacetate and fumarylacetoacetate accumulate in the liver and kidneys. They possess a reactive double bond and can therefore react with macromolecules to assume the properties of alkylating substances. In addition, intracellular glutathione deficiency develops due to the stable complex formation with glutathione, favouring lipid peroxidations. Enhanced formation of 5-aminolaevulinic acid can also be observed during occasional attacks of acute intermittent porphyria (G. Mitchel et al., 1990). [Pg.593]

Cyclophosphamide is a prodrug which is converted into active metabolites in the liver. Urotoxic side effects must be anticipated they can be suppressed by the additional administration of sodium-2 mercaptoethanesulphonate. This alkylating substance has a strong immunosuppressive effect therefore, it is occasionally used to prevent graft rejection or (at a low dosage) in autoimmune hepatitis, (s. p. 686)... [Pg.856]

Nature, formation and occurrence of alkylating substances in tobacco and tobacco smoke] in Compounds having alkylating action, Verband derCigarettenindustrie, Wissenschaftliche Forschungstelle (1964) 121-130. [Pg.1358]

Alkyl Quaternary Ammonium Compounds. These have long been applied in certain special fields, and their further use may well be warranted in many instances. A detailed specific example of this application is given under Codeine, where the preparation and use of phenyltrimethyl-ammonium chloride, C8HsN(CH3)3Cl, is described. These quaternary alkyl substances have also been recommended for alkylations leading to pbenetole, antipyrine, pyramidone, acriflavine, and caffeine. [Pg.817]

European Commission Recommendation 2010/161/UE on the monitoring of perfluoro-alkylated substances in food. Off. J. Eur. Union L68, 2010 22-23. [Pg.330]

Kallenbom R, Berger U, Jamberg U (2004) Perfluorinated alkylated substances (PFAS) in the Nordic environment. Nordic Council of Ministers, Copenhagen, Denmark... [Pg.98]

Clara M, Gans O, Weiss S, Sanz-Escribano D, Scharf S, Scheffknecht C (2009) Perfluorinated alkylated substances in the aquatic environment an Austrian case study. Water Res 43(18) 4760-4768... [Pg.102]

Jahnke A, Berger U. Trace analysis of per- and polyfluorinated alkyl substances in various matrices— how do current methods perform J Chromatogr A 2009 1216(3) 410—21. [Pg.385]

Gonzalez-Barreiro C, Martinez-Carballo E, Sitka A, Scharf S, Gans O. Method optimization for determination of seleded perfluorinated alkylated substances in water samples. Anal Bioanal Chem 2006 386(7—8) 2123—32. [Pg.385]

Navarro I, Sanz P, Martinez MA. Analysis of perfluorinated alkyl substances in Spanish sewage sludge by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 2011 400(5) 1277-86. [Pg.388]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...