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Glutathione deficiency

Martensson, J. and Meister, A. (1991). Glutathione deficiency decreases tissue ascorbate levels in newborn rats ascorbate spates glutathione and proteas. Proc. Natl Acad. Sci. USA 88, 4656-4660. [Pg.140]

Cantin, A.M., Hubbard, R.C. and Crystal, R.G. (1989). Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract of patients with idiopathic pulmonary fibrosis. Am. Rev. Resp. Dis. 139, 370-372. [Pg.228]

H17. Hirono, A., Iyori, H., Sekine,I.,Ueyama, J., Chiba, H., Kanno, H., Fujii, H and Miwa, S., Three cases of hereditary nonspherocytic hemolytic anemia associated with red blood cell glutathione deficiency. Blood 87,2071-2074 (1996). [Pg.43]

Kerklaan PRM, Zoetemelk CEM, Mohn GR. 1985. Mutagenic activity of various chemicals in Salmonella strain TA100 and glutathione-deficient derivatives On the role of glutathione in the detoxification or activation of mutagens inside bacterial cells. Biochem Pharmacol 34 2151-2156. [Pg.122]

Meister A. 1995. Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271 35 42. [Pg.449]

Lauterburg BH, Velez ME. Glutathione deficiency in alcoholics risk factor for paracetamol hepatotoxicity. Gut 1988 29 1153-1157. [Pg.707]

Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, et al. 1989. Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 2 1294-1298. [Pg.303]

Jacobsen JPR, Rodriguiz RM, Mork A, Wetsel WC. 2005. Monoaminergic dysregulation in glutathione-deficient mice Possible relevance to schizophrenia Neuroscience 132 1055-1072. [Pg.306]

The gene mutation inhibits hydrolytic cleavage of fumarylacetoacetate into fumarate and acetoacetate. Consequently, the toxic precursors maleylacetoacetate and fumarylacetoacetate accumulate in the liver and kidneys. They possess a reactive double bond and can therefore react with macromolecules to assume the properties of alkylating substances. In addition, intracellular glutathione deficiency develops due to the stable complex formation with glutathione, favouring lipid peroxidations. Enhanced formation of 5-aminolaevulinic acid can also be observed during occasional attacks of acute intermittent porphyria (G. Mitchel et al., 1990). [Pg.593]

Most of the cutaneous adverse reactions to sulfonamides are associated with increased in vitro reactivity to sulfonamide metabolites, such as unstable hydroxyl-amines (160,161). In some cases glutathione deficiency has been proposed as a major mechanism. This seems to be important in patients with AIDS, in whom glutathione deficiency is frequent, and in whom skin rashes are much more common than in other patients (160,162). A predominance of slow acetylator phenotype has also been observed among patients with sulfonamide hypersensitivity reactions, and an association with the phenotypes HLA-A29, B-12, and DR-7 in patients with bullous cutaneous reactions (161,163-165). [Pg.3222]

Prins HK, Oort M, Zurcher C, Beckers T. Congenital nonspherocytic hemolytic anemia, associated with glutathione deficiency of the erythrocytes. Hematologic, biochemical and genetic studies. Blood 1966 27 145-66. [Pg.641]

Radi R, Turrens JF, Chang LY, Bush KM, Crapo JD, Freeman BA (1991) Detection of catalase in rat heart mitochondria. J Biol Chem 266 22028-22034 Meister A (1995) Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271 35-42... [Pg.232]

Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA. (2006) Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci 9 119-126. [Pg.196]

Young JD, Crowley C, Tucker EM. 1981. Haemolysis of normal and glutathione-deficient sheep erythrocytes by selenite and tellurite. Biochem Pharmacol 30 2527-2530. [Pg.403]

Genetic Glucose-6-phosphate dehydrogenase deficiency, glutathione deficiency, glutathione reductase deficiency, thalassemia, tyrosinemia, Wilson s disease, 6-aminolevulinic acid dehydratase deficiency... [Pg.127]

Meister, A. (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal applications in research and therapy. Pharmacol. Ther. 51 155-194. [Pg.496]

Treacy E, et al. Glutathione deficiency as a complication of methylmalonic acidemia response to high doses of ascorbate. J Pediatr. 1996 129(3) 445-8. [Pg.199]


See other pages where Glutathione deficiency is mentioned: [Pg.132]    [Pg.681]    [Pg.66]    [Pg.284]    [Pg.689]    [Pg.456]    [Pg.68]    [Pg.174]    [Pg.181]    [Pg.304]    [Pg.58]    [Pg.21]    [Pg.529]    [Pg.2686]    [Pg.3222]    [Pg.224]    [Pg.37]    [Pg.194]    [Pg.10]   
See also in sourсe #XX -- [ Pg.127 ]




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Glutathione metabolism, enzyme deficiency

Glutathione peroxidase deficiency

Glutathione reductase deficiency

Glutathione synthase deficiency

Glutathione synthetase deficiency

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