DTIC-Dome

Dacarbazine DTIC-Dome) is activated by photodecomposition and by enzymatic A-demethylation. Eventual formation of a methyl carbonium ion results in methylation of DNA and RNA and inhibition of nucleic acid and protein synthesis. As with other alkylating agents, cells in all phases of the cell cycle are susceptible to dacarbazine. [Pg.642]

Dacarbazine DTIC-Dome Malignant melanoma refractory Hodgkin s lymphomas Gl distress (nausea, vomiting, loss of appetite] blood disorders (leukopenia, thrombocytopenia]... [Pg.570]

Dacarbazine (DTIC-Dome) is metabolized to an active alkylating substance. It is used in the treatment of malignant melanoma and causes myelosuppression. [Pg.113]

D Detimedac (medac) GB DTIC-DOME (Bayer) USA DTIC-DOME (Bayer)... [Pg.571]

SYNS DETICENE DIG (DIMETHYLTRIAZENO)-IMIDAZOLECARBOXAMIDE 4-(DIMETHYL-TRIAZENO)-MIDAZOLE-5-CARBOXAMIDE 4 (3,3-DIMETHYL-l-TRIAZENO)ftnDAZOLE-5-CARBOX-AMIDE 4-(5)-(3,3-DIMETPra.-l TRIAZENO)IMIDAZ-OEE-5(4)-CARBOXAMIDE 5-(DIMETPm.TRIAZENO)-IMIDAZOLE-4-CARBOXAMIDE D 5-(3,3-DIMETHYL-TRIAZENO)EVnDAZOLE-4-CARBOXAMIDE 5-(3,3-DIMETHYL-1 -TRIAZENO)MIDAZOLE-4-CARBOX-AMIDE 5-(3,3-DIMETHYL-l-TRIAZENYL)-lH-IMIDAZOLE-4-CARBO-XAMIDE DTIC DTIC-DOME NCI-C04717 NSC-45388... [Pg.415]

Reconstituted solutions (lOmg/mL, pH 3.5 ) are reported to be stable for at least 24 hours at room temperature and at least 96 hours when refrigerated, and when photoprotected (40). Solutions, further diluted with 5% dextrose or 0.9% sodium chloride diluent, remain stable for 24 hours under refrigeration and 8 hours when stored at room temperature and photoprotected (Product Information, DTIC-Dome, 1998). [Pg.408]

DTIC-Dome) (Asendin) (Periactin and (Declomycin (Aralen) (Thorazine (Midamor) (Diabinese (Captoen)... [Pg.316]

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