Alkylating agents lung cancer

Lomustine (CCNU) -nitrosourea alkylating agent cell cycle independent -bone marrow suppression (delayed, prolonged, and cumulative) -nausea and vomiting -pulmonary fibrosis Lung Cancer... 

Polymer (VI) has been shown to have antitumor activity against adenocarcinoma 755, Dunning ascites leukemia. Friend leukemia virus, and Lewis lung carcinoma. In the latter case, polymer (VI) showed activity about equal to that of cyclophosphamide (an alkylating agent) and was more effective than 6-mercaptopurine (an antimetabolite) ( ). The DIVEMA polymer (V) Is also active against some cancer causing viruses such as Friend leukemia, Moloney sarcoma and Rauscher leukemia ( ). 

Pujol JL, Carestia L, Daures JP. Is there a case for cisplatin in the treatment of small-cell lung cancer A meta-analysis of randomized trials of a cisplatin-containing regimen versus a regimen widiout diis alkylating agent. Br J Cancer 2000 83 8-15. 

Cisplatin, an alkylating agent, is indicated as an adjunctive therapy in metastatic testicular cancer adjunctive therapy in metastatic ovarian cancer, head and neck cancers, lung cancer, and esophageal cancer, and in the treatment of advanced bladder cancer (see also Figure 15). 

In summary, ifosfamide, an alkylating agent with anti-neoplastic properties (1.2 g/mVday fV for 5 days), is indicated in the treatment of testicular cancer. In addition, ifosfamide has been used in lung cancer, Hodgkin s and non-Hodgkin s lymphoma, breast cancer, acute and chronic lymphocytic leukemia, ovarian cancer, and sarcomas. 

Thiotepa, an alkylating agent with antineoplastic properties, is indicated in breast, lung, and ovarian cancer, Hodgkin s disease, lymphomas, and in bladder tumor and neoplastic effusions. 

Uracil mustard, an alkylating agent with antineoplastic activity (1 to 2 mg p.o. daily for three months), is indicated in treatment of chronic lymphocytic and myelocytic leukemia Hodgkin s disease, non-Hodgkin s lymphomas of the histiocytic and lymphocytic types reticulum cell sarcoma lymphomas mycosis fungoides polycythemia vera and ovarian, cervical, and lung cancer. 

Cisplatin i i f Alkylating agent— cross-links DNA strands Testicular, ovarian, bladder, lung cancer Nausea, vomiting (use ondansetron) nephrotoxicity (use amifostine) neurotoxicity (deafness)... 

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