Alcohols reagent

To circumvent the need for strong acid and allow the dehydration of secondary alcohols, reagents have been developed that are effective under mild, basic conditions. One such reagent, phosphorus oxychloride (POCI3) in the basic amine solvent pyridine, is often able to effect the dehydration of secondary and tertiary alcohols at 0 °C. 

Sec-butyl alcohol, reagent grade (Eastman Organic Chemicals Cat No 943 or equivalent)... 

There are also a vast number of reactions known between alkoxides and non-trivial alcoholic reagents such as glycol, catechols, alkanolamines and hydroxylamines. The fundamental reaction involves elimination of alcohol, but with the reaction products complicated by the nature of chemistry of the other substituents.1... 

The Meerwein-Pondorff-Verley (MPV) reduction of aldehydes and ketones to the corresponding alcohols [61] is another example of a long-standing technology. The reaction mechanism involves coordination of the alcohol reagent, usually isopropanol, and the ketone substrate to the aluminum center, followed by hydride transfer from the alcohol to the carbonyl group. In principle, the re-... 

In the presence of a Mannich base, hydroxymethyl derivatives 268 may behave, in turn, as alcoholic reagents, thus affording amino group replacement with formation of the symmetrical ether 269 (R = R —CH ). Indeed, alcohols and phenols allow the synthesis of ethers 269, starting from phenolic Mannich bases as well as from the methiodides of aminomethylfcrrocenes, by reaction with alkoxide or phenoxide. Good results have been obtained with a thioporphirine Mannich base and zinc acetate. Esters 270 (Fig. 102) can be synthesized from various Mannich bases such as those derived from tropolones or purines, which are converted into acetoxymethyl... 

Although aldehydes are more easily ozidized than alcohols, reagents and conditions are similar in the conversion of both substances to acids. Sulfuric-chromic acid mixture has been used to prepare propionic acid from the alcohol (65%), heptanoic acid from the aldehyde (70%), and furoic acid from furfural (75%). ° Alkaline permanganate is employed in the preparation of methyldiphenylacetic acid from the aldehyde (45%) and ethyl-n-butylacetic acid from the aldehyde or alcohol (74%). ° Acid permanganate is used for the oxidation of heptaldehyde to heptanoic acid (78%) and 6-methyl-l-octanol to 6-methyloctanoic acid (66%). ... 

A currently employed method for dehalogenation of alkyl halides is to use a Li- or Na-alcohol reagent system. This method is effective not only for simple alkyl halides but also for the reduction of a halogen atom attached to a bridgehead. Carbon-carbon unsaturated bonds are not affected under the conditions, as shown in Scheme 5. ... 

The alkali metal dithiocarbonates (xanthates) are prepared by reacting carbon disulfide with alcohols or phenols in the presence of an alkali metal hydroxide (usually KOH) using as solvent an excess of alcohol reagent,176 a hydrocarbon, or acetone.177... 

Compounds with Ceric Nitrate Alcohol Reagent. 

The resin was placed in a vacuum of 30 in Hg for two hours, then sealed in a nitrogen atmosphere. Resin with a higher hydroxyl content was prepared in a similar manner except before sealing the bottle, isopropyl alcohol (Reagent, Lehigh Valley Chemical) was added. Characterization of these materials by a modified procedure of Knoll et al (14) gave the epoxide content. Table I. Hydroxyl content was calculated from the structural formula. 

The results of this preliminary study have shown that the introduction of a carbon-carbon double bond into an alcohol reagent can lead to the formation of oxygenate products in high selectivity and this may be of significance for the use of zeolites for the synthesis of fine chemicals. 

Material Safety Data Sheet Methyl Alcohol, Reagent ACS, 99.8% (GC). Department of Chemistry, Iowa State University. http //avogadro.chem.iastate.edu/MSDS/methanol.htm (accessed on October 17, 2005). 

Scheme 10-111 Pt-catalyzed intramolecular hydrosilylation of allylic amines provides 1,2-amino alcohols. Reagents and conditions i) BuLi, Me2SiHCl, Et20 ii) [Pt [(CH2=CH)Me2Si]20 2], rt iii) EDTA 2Na, hexane, rt then 30% H2O2, KF, KHCO3, MeOH, THF, rt.

Electrophilic addition to alkenes ch19 Reduction of benzene rings Reagents for oxidation of alcohols Reagents for oxidation of alkenes Protection of aldehydes, ketones, alcohols, and amines Synthesis of peptides Cycloadditions ch34... 

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