Synthesis of Alcohols Using Grignard and Organolithium Reagents

The basicity of Grignard and organolithium reagents has several applications. One is in the preparation of analogous organometallics of acetylene and terminal alkynes. 

Another is in introducing deuterium at a specific position in a carbon chain. 

Lithium diisopropyiamide is often used as a strong base in organic synthesis and is prepared by an acid-base reaction between butyiiithium and /V,/V-diisopropylamine. Complete the equation shown with appropriate structurai formuias and use curved arrows to show the flow of electrons. What is the vaiue of the equiiibrium constant K1 

5 Synthesis of Alcohols Using Grignard and Organolithium Reagents 

The main synthetic application of Grignard and organolithium reagents is their reaction with carbonyl-containing compounds to produce alcohols. Carbon-carbon bond formation is rapid and exothermic when Grignard and organolithium reagents react with an aldehyde or ketone. 

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