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Alcohol naltrexone

Alcohol, Naltrexone is a p-opioid receptor antagonist first synthesized in the opioid 1960s. Naltrexone was approved by the FDA for the treatment of opioid addiction treatment in 1984 and alcohol addiction in 1994 [247]. Naltrexone blocks the euphoric effects of opioids by binding competitively to opioid receptors, but does little to curb craving for opioids. Because naltrexone is an opioid antagonist there is little risk of abuse or dependence given that it does not have intrinsic opiate effects and therefore is not reinforcing [248]. [Pg.594]

OPRM1 p-Opioid receptor rsl799971 (A118G) Alcohol Naltrexone... [Pg.596]

Opioidergic agents. Naltrexone and nalmefene, opioid antagonists with no intrinsic agonist properties, have been studied for the treatment of alcohol dependence. Naltrexone has been studied much more extensively than nalmefene for this indication. In 1984 naltrexone was approved by the FDA for the treatment of opioid dependence, and in 1994 it was approved for the treatment of alcohol dependence. Nalmefene is approved in the United States as a parenteral formulation for the acute reversal of opioid effects (e.g., after opioid overdose or analgesia). [Pg.22]

Using a primary-care model of treatment, O Malley et al. (2003) initially treated alcohol-dependent patients with open-label naltrexone for 10 weeks, in combination with either CBT or primary care management (PCM), a less intensive, supportive approach. They found no effect of psychosocial treatment on response to treatment, although CBT was associated with a lower risk of drinking. Treatment responders from this study were then randomly assigned to one of two placebo-controlled 24-week continuation studies in... [Pg.25]

Acamprosate. Acamprosate (calcium acetylhomotaurinate), an amino acid derivative, affects both GABA and excitatory amino acid (i.e., glutamate) neurotransmission (the latter effect most likely being the one that is important for its therapeutic effects in alcoholism). Initially evaluated in a singlecenter trial in France, acamprosate was shown to be twice as effective as placebo in reducing the rate at which alcoholic patients returned to drinking (Lhuin-tre et al. 1985). The safety and efficacy of the medication have been studied most widely in Europe, and three of these studies provided the basis for the recent approval of acamprosate by the FDA for clinical use in the United States. As with naltrexone, there exist a number of meta-analytic studies that provide consistent evidence of the efficacy of the medication in the treatment of alcohol dependence. [Pg.28]

In general, with the exception of the central role that benzodiazepines play in the treatment of alcohol withdrawal, the use of medications that have been approved for alcoholism rehabilitation remains very limited. A survey of nearly 1,400 addiction physicians showed that they prescribed disulfiram to only 9% of their alcoholic patients and that naltrexone was prescribed for only slightly higher proportion of patients (13%) (Market al. 2003). These tesults contrast with findings for antidepressants, which were prescribed to 44% of alcoholic patients. Although neatly all of these physicians had heatd of both disulfiram and naltrexone, their self-reported level of knowledge of these medications was much lowet than that of antidepressants. [Pg.39]

Anton RF, Moak DH, Latham PK, et al Posttreatment results of combining naltrexone and cognitive-behavior therapy for the treatment of alcoholism. J Clin Psycho-pharmacol 21 72—77, 2000... [Pg.41]

Bouza C, Magro A, Munoz A, et al Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence a systematic review. Addiction 99 811-828, 2004... [Pg.42]

Kranzler HR, Van Kirk J Efficacy of naltrexone and acamprosate for alcoholism treatment a meta-analysis. Alcohol Clin Exp Res 23 1335-1341, 2001 Kranzler HR, Babor TF, Lauerman R Problems associated with average alcohol consumption and frequency of intoxication in a medical population. Alcohol Clin Exp Res 14 119-126, 1990... [Pg.48]

Kranzler HR, Tennen H, Penta C, et al Targeted naltrexone treatment in early problem drinkers. Addict Behav 22 431 36, 1997 Kranzler HR, Modesto-Lowe V,NuwayserES Asustained-release naltrexone preparation for treatment of alcohol dependence. Alcohol Clin Exp Res 22 1074—1079, 1998 Kranzler HR, Armeli S, Tennen H, et al Targeted naltrexone for early problem drinkers. [Pg.48]

Kranzler HR, Wesson DR, Billot L Naltrexone depot for treatment of alcohol dependence a multicenter, randomized, placebo-controlled clinical trial. Alcohol Clin... [Pg.48]

Krystal JH, Cramer JA, Krol WF, et al Naltrexone in the treatment of alcohol dependence. N Eng J Med 343 1734-1739, 2001 Krystal JH, Petrakis IL, Limoncelli D, et al Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Neuropsychopharmacology 28 2020-2028, 2003a... [Pg.48]

Landabaso MA, Iraurgi 1, Sanz J, et al. Naltrexone in the treatment of alcoholism two-year follow up results. Eur J Psychiatry 13 97-103, 1999... [Pg.48]

Littleton J, Zieglgansberger W Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict 12 (suppl 1) S3-S11,2003... [Pg.49]

Petrakis IL, O Malley S, Rounsaville B, et al Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology (Berl) 172 291-297, 2004... [Pg.51]

Rubio G, Jimenez-Arriero MA, Ponce G, et al Naltrexone versus acamprosate one year follow-up of alcohol dependence treatment. Alcohol Alcohol 36 419 25,... [Pg.52]

Salloum IM, Cornelius JR, Thase ME, et al Naltrexone utility in depressed alcoholics. Psychopharmacol Bull 34 111—115, 1998... [Pg.52]

Streeton C, Whelan G Naltrexone, a relapse prevention maintenance treatment of alcohol dependence a meta-analysis of randomized controlled trials. Alcohol Alcohol 36 544-552, 2001... [Pg.53]

Kleber HD, Weissman MM, Rounsaville BJ, et al Imipramine as treatment for depression in addicts. Arch Gen Psychiatry 40 649-633, 1983 Kleber HD, Riordan CE, Rounsaville BJ, et al Clonidine in outpatient detoxification from methadone maintenance. Arch Gen Psychiatry 42 391-394, 1983 Kleber HD, Topazian M, Gaspari J, et al Clonidine and naltrexone in the outpatient treatment of heroin withdrawal. Am J Drug Alcohol Abuse 13 1-17, 1987 Kornetsky C. Brain stimulation reward, morphine-induced stereotypy, and sensitization implications for abuse. Neurosci Biobehav Rev 27 777-786, 2004 Kosten TR, Kleber HD Buprenorphine detoxification from opioid dependence a pilot study. Life Sci 42 633-641, 1988... [Pg.102]

Umbricht A, Hoover DR, Tucker MJ, et al Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection. Drug Alcohol Depend 69 263-272, 2003 Villagomez RE, Meyer TJ, Lin MM, et al Post-traumatic stress disorder among inner city methadone maintenance patients. Subst Abuse Treat 12 253—257, 1995 Mining E, Kosten TR, Kleber H Clinical utility of rapid clonidine-naltrexone detoxification for opioid abusers. Br J Addict 83 567-575, 1988 Washton AM, Pottash AC, Gold MS Naltrexone in addicted business executives and physicians. J Clin Psychiatry 45 39 1, 1984 Wesson DR Revival of medical maintenance in the treatment of heroin dependence (editorial). JAMA 259 3314-3315, 1988... [Pg.109]

Kranzler HR, Van Kirk J Efficacy of naltrexone and acamprosate for alcoholism treatment a meta-analysis. Alcohol Clin Exp Res 23 1335-1341, 2001... [Pg.308]


See other pages where Alcohol naltrexone is mentioned: [Pg.524]    [Pg.602]    [Pg.524]    [Pg.602]    [Pg.237]    [Pg.446]    [Pg.181]    [Pg.15]    [Pg.22]    [Pg.23]    [Pg.23]    [Pg.23]    [Pg.23]    [Pg.24]    [Pg.24]    [Pg.25]    [Pg.25]    [Pg.26]    [Pg.27]    [Pg.28]    [Pg.35]    [Pg.39]    [Pg.40]    [Pg.45]    [Pg.46]    [Pg.47]    [Pg.51]    [Pg.54]    [Pg.90]    [Pg.100]    [Pg.105]    [Pg.327]   
See also in sourсe #XX -- [ Pg.1197 ]




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