Naltrexone in alcohol dependence

Latt NC, Jurd S, Houseman J, Wutzke SE (2002) Naltrexone in alcohol dependence a randomised controlled trial of effectiveness in a standard clinical setting. Med J Aust 176 530-534... 

In a study in 24 healthy subjects, the concurrent use of naltrexone 50 mg daily and acamprosate 2 g daily for 7 days modestly increased the rate and extent of absorption of acamprosate, as indicated by a 33% inerease in maximum level, a 33% reduction in time to maximum level, and a 25% increase in AUC. There was no change in naltrexone pharmaeokinetics. Similarly, an increase in acamprosate levels was seen in a study of the use of acamprosate and naltrexone in alcohol-dependent subjeets." No particular adverse events were identified on concurrent use, " suggesting that the drugs may be used together. 

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