Dipropionate

Fluoro-llb-hydroxy-16b-methyl-17a,21-bis(l-oxopropanoxy)-pregna-l,4-diene-3,20-dione. See b-Methasone dipropionate. 

Hematoporphyrin (3,3 -[7,12-bis-(l-hydroxyethyI)-3,8,13,17-tetramethyl-porphyrin-2,18-diyl]-dipropionic acid) [I4459-29-I] M 598.7, pKE,t Purified by dissolving in EtOH and... 

The synthetical experiments started by Openshaw and Robinson have for their immediate objective the preparation of one of the possible degradation products of strychnine, and a beginning has been made by the preparation of the lactam of hexahydrocarbazole-1 ll-/SjS -dipropionic acid (XXIV), which reproduces a portion of the strychnine molecule as represented in Robinson s formula (Ilia, p. 574), and in sulphuric acid gives a purple colour with a trace of potassium dichromate (Otto reaction). 

This was transformed into the quaternary d-bromocamphorsulphonate, m.p. 265°, but no resolution has yet been effected. The lactam of 3-carboxyhexahydrocarbazole-1 ll-)3 8 -dipropionic acid (XXIV, with a carboxyl group at C ), CigH jO N, rn.p. 257-8°, has also been prepared. The same authors, with Holmes, have synthesised the lactam of 11-ethylhexahydrocarbazole-l-)3-propionic acid, Ci,H3iON, m.p. 106-8-107-5°, of which (XXrV) is a carboxy-derivative. 

Estradiol Benzoate Estradio Cypionate Estradiol Dipropionate... 

Halogenation of the 7 position also proves compatible with good antiinflammatory activity. Construction of this compound, aclomethasone dipropionate (80), starts by introduction of the required unsaturation at the 6,7 position by dehydrogenation with DDQ (76). The highly hindered nature of the hydroxyl at position 17 requires that a roundabout scheme be used for formation of the corresponding ester. Thus treatment of 76 with ethyl orthoformate affords first the cyclic orthoformate This then rearranges to the 17 ester on exposure to acetic acid. Acylation of the 21 alcohol is accomplished in straightforward fashion with... 

Estrazinol 2, 142 Estradiol I, 162 2, 136 Estradiol benzoate 162 Estradiol cypionate 1, 162 Estradiol dipropionate 1, 162 Estradiol hexabenzoate T, 162 Estradiol valerate 162 Estramustine 83... 

Chemical Name 9-chloro-11/3,l7,21-trihydroxy-16/3-methylpregna-1,4-diene-3,20-dione dipropionate... 

The excess of N-chlorosuccinimide is destroyed by the addition of about 15 drops of allyl alcohol and 180 ml of water is then added with stirring. This mixture is held at 0°C for about one hour. The precipitated 16/3-methyl-1,4-pregnadiene-9o-chloro-11/3,17o,21-triol-3,20-dione-21-acetate is recovered by filtration. A solution of 250 mg of the chlorohydrin in 5 ml of 0.25N perchloric acid in methanol is stirred for about 18 hours at room temperature to produce 16/3-methyl-9o-chloro-11/3,17o,21-trihydroxy-1,4-pregnadiene-3,20-dione which is recovered by adding water to the reaction mixture and allowing the product to crystallize. Propionic anhydride is then used to convert this material to the dipropionate. 

Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg),MP 117°C (decomposition). 

A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylene-dihydrotestosterone which was treated with hydrogen, in methanol solution. 

Betamethasone dipropionate 6-FIuoro-2-methyl tetrahydroquinoline Flumequine... 

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