AIDS, cachexia

Dronabinol is an antiemetic/antivertigo agent, which is indicated in the control of chemotherapy-induced nausea and vomiting unresponsive to other antiemetics and appetite stimulation in AIDS cachexia. 

AIDS (acquired immunodeficiency syndrome) is the final stage of disease caused by infection with HIV. In this stage, the vims infection has severely affected the immune system, causing a depletion of CD4+ T-helper cells. AIDS is characterized by the manifestation of typical diseases caused by opportunistic infections (Pneumocystis carinii pneumonia, CMV retinitis, candidiasis of the esophagus, cerebral toxoplasmosis), neurological manifestations, cachexia, or certain tumors (Kaposi sarcoma of the skin, B-cell lymphoma). 

Cachexia refers to a physical wasting due to loss of muscle and fat. Cachexia is often found in end-stage cancer patients but is also caused by autoimmune disorders or by infectious diseases such as AIDS and tuberculosis. 

Cachexia is more difficult to treat, although it may resolve following treatment of the underlying malignancy. Nutritional consultation may be of aid, although cachexia is thought to be more attributable to internal pathophysiologic processes than malnutrition. 

AVR118, reticulose Peptide nucleic acids Immune augmentation AIDS Related Anorexia/Cachexia... 

Cachexia accompanies many diseases, which include sepsis, diabetes and AIDS, as weU as cancer (Chapter 16). The metabolic changes in cachexia are an extension of those presented above, but are more severe. An overview of the metabolic changes in cancer is given in Figure 21.24. The metabolic changes that occur in patients, after trauma and during cancer can be compared by reference to Table 21.5. 

AIDS wasting syndrome (suspension only) - Treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). 

Cachexia is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite. It is seen in patients with cancer, acquired immunodeficiency syndrome (AIDS), chronic obstructive pulmonary disease and congestive heart failure. Underlying causes are poorly understood, but there is an involvement of inflammatory cytokines, such as TNF-a, IFN-y, IL-6 and tumour-secreted proteolysis-inducing factor. Related syndromes are kwashiorkor and marasmus, although these are most often symptomatic of severe malnutrition. 

Anorexia, cachexia or significant weight loss due to AIDS Melanoma... 

The role of CDF/LIF after injury to body systems in general may be analogous to that discused in the previous Section with respect to the nervous system. Overproduction of CDF/LIF causes cachexia (Metcalf and Gearing, 1989). OSM possesses a potent mitogenic activity on AIDS-Kaposi s sarcoma-derived cells whereas CDF/LIF stimulates HIV replication in mononuclear phagocytes (Miles et al., 1992 Broor et al., 1994). On the other hand, the presence of CDF/LIF at a subthreshold level may be advantageous for defense against invasive stimuli, endotoxic shock, hyper-oxia, and radiation injury (Alexander et al., 1992 ... 

Patients with advanced cancer, human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) and a number of other chronic diseases are frequently undernourished. Physically they show all the signs of marasmus, but there is considerably more loss of body protein than occurs in starvation. The condition is called cachexia, from the Greek Ka% io for in a poor condition ). A number of factors contribute to the problem ... 

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