Anti-lipid

Kuno, A., Sugiyama, Y., Katsuta, K., Sakai, H. and Takasugi, H. (1992). Studies on cerebral protective agents. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities. Chem. Pharm. Bull. 40, 2423-2431. 

There are other ways in which endotoxins may act to produce cotton dust induced airway disease. These include 1) an instrinsic toxicity due to lipid A, responsible for both pyro-genicity and tissue damage 2) a hypersensitivity reaction involving anti-lipid A antibodies. Further, changes in mechanical properties of the lung could be explained by the release of histamine or serotonin caused by endotoxins. 

Bhart, N.M., Bieber, M.M., Chapman, C.J. Human anti-lipid A monoclonal antibodies bind to human B cells and i-antigen on core red blood cells. J Immunol 151 (1993) 5011-5021. 

Helmerhorst, E.J., Maaskant, J.J., Appelmelk, B.J. Anti-lipid A monoclonal antibody centoxin (HA-1 A) binds to a wide variety of hydrophobic ligands. Infect Immun 66 (1998) 870-873. 

Warren, H.S., Amato, S.F., Fitting, C., Black, K.M., Loiselle, P.M., Pasternack, M.S., CavaiUon, J.M. Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide. J Exp Med 177 (1993) 89-97. 

Anuradha, C. and Ravikumar, P. 1998. Anti-lipid peroxidative activity of seeds of fenugreek (Trigonella foenum graecum). Med. Sci. Res. 26, 317-321. 

Fisher CJ Jr, Zimmerman J, Khazaeh MB, Albertson TE, Dellinger RP, Panacek EA, Foulke GE, Dating C, Smith CR, LoBugho AF. Initial evaluation of human monoclonal anti-lipid A antibody (HA-1 A) in patients with sepsis syndrome. Crit Care Med 1990 18(12) 1311-15. 

Since ancient times, the roots of Scutellaria baicalensis have been used to treat allergic and inflammatory diseases in China and Japan. We reported the isolation from these roots of three new compounds, i.e., 2 S), 2, 5,6, 7-tetetahydroxy flavanone[25], 2 R), 3(i )-2, 3,5,6, 7-pentahydroxyflavanone and 2, 5,5, 7-tetrahydroxy-6, 8-dimethoxy-flavone, as antibacterial or anti-lipid peroxidation substances [26, 27], as well as six flavonoids, i.e., baicalein, bailcalin, oroxylin A, wogonin, skullcapflavone II, etc. Furthermore, we found that baicalein and baicalin "Fig. (47)" suppressed the development of secondary lesions in adjuvant-induced arthritis in rats "Fig. (48)". 

XW Yang, M Hattori, T Namba, DF Chen, GJ Xu. Anti-lipid peroxidative effect of an exract of the stem of Kadsnra heterochta and its major constituent, kadsnrin, in mice. Chem Pharm Bull 40 406 409, 1992. 

Niacin has wide spectrum anti-lipid lowering effect as it has shown to decrease LDL-c, triglyceride and Lp(a), and increase HDL. 

Pharmaceutical drugs from the statin class have also been determined using VACNT-based electrodes. The pharmaceutical class of statins includes substances of anti-lipid activity acting, therefore, in the reduction of the levels of cholesterol in blood. This activity of statins is derived from its action on the HMG-CoA reductase enzyme (3-hydro q -3-methylglutaiyl CoA reductase), which catalyses the production of mevalonic acid, the precursor of cholesterol biosynthesis. Three papers dedicated to... 

A variety of diarylheptanoids present in Alpinia qfficinarum were determined to display antioxidative activity demonstrated by an anti-lipid peroxidation assay (2). The DPPH assay has been extensively used to test the free radical scavenging ability of various chemicals 8,9) and therefore we used the DPPH method to explore five isolated compounds capacity to act as free radical scavengers. 

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