ADHESION PREVENTION

Post-operation tissue adhesion can occasionally cause serious complications. Materials for tissue adhesion prevention should be flexible and tough enough to provide a tight cover over the traumatized soft tissue. In addition, they should be 

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Frixen, U. W., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Loech-ner, D. and Birchmeier, W. (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol. 113, 173-185. 

Adhesiveness prevents detachment from the surface of the epithelium, and causes firm attachment to the underlying cellular layer. 

Glass fibers are extensively used by industiy because of their reinforcing effect, and the improvements they produce in thermal properties such as a reduction in thermal expansion and an increase in heat deflection temperature. The most challenging tasks of fiber application include the incorporation process which must be designed to prevent breakage, improve matrix fiber adhesion, prevent fiber corrosion in some environments, and develop proper fiber orientation. 

RANTES 17 Eo, Ep, mesotheUal, F, SMC, Me, K, T cells. Mo, EC, platelets IE-1/3, TNFa, angiotensin 11, respiratory syncytial virus, HEV, influenza Activates T, increases (3 integrin adhesion, prevents HEV infection Attracts Eo and BS, histamine release... 

Inhibitors of sugar-specific adhesion prevent infection in animals and humans... 

Nanomaterials science for interfacing with living tissues, for delivery of pharmaceuticals, tissue-engineering scaffolds, wound repair, adhesion prevention, and other biological agents and medical devices. 

Immunoglobulin G 10-30 glass polvvinyl toluene PHEMA-PEMA platelets leucocytes fibroblasts and red cells adhesion and release enhanced (5) phagocytosis enhanced (6) adhesion prevented (7)... 

Albumin 40-60 glass polyethylene falcon dishes platelets red cells fibroblasts adhesion and release decreased (5) strength of adhesion decreased (14) adhesion prevented (8)... 

Di Zerega G. Contemporary adhesion prevention. Fertil Steril 1994 61 219-235. 

Thornton, J. et al. Clinical evaluation of 0.5% ferric hyaluronate adhesion prevention gel for the reduction of adhesion following peritoneal cavity surgery Open-label pilot study. Hum. Reprod., 13, 1480, 1998. 

This study is designed to compare the effect of ftie gel-former selected in Section 13.3.4.2 on POA wifti a size 6-0 silk suture/saline, HA, and C-TA as basic barrier and positive controls, respectively. The adhesion formation was studied using a rat sidewall model. The abdominal cavity was entered into in female Sprague-Dawley rats through a small midline incision. A 1-cm2 area of peritoneal sidewall was excised wifti a scalpel blade. The 6-0 silk was then sutured aroimd the perimeter of ftie excised area with a square knot at each corner. Aliquots of either the gel-former (100 pL) or the controls (1 mL) were injected on tiie excised site. One week postoperative, the adhesion prevention score was recorded for the different formulations on a scale of 0 to 10. A score of 10 represents maximum adhesion whereas 0 reflects the absence of any adhesions. Adhesion rating criteria were based on the work by Bums et al. ... 

Holtz, G., G5mecologic surgery and adhesion prevention Overview of classical adjuvant approaches. Prog. Clin. Biol. Res., 381, 81, 1993. 

DeGherney, A. H., diZerega, G. S. et al.. Clinical problem of intraperitoneal postsurgical adhesion formation following general surgery and the use of adhesion prevention barriers, Surg. Clin. N. Am., 77, 671,1997. 

Nordic Adhesion Prevention Study Group, The efficacy of Interceed(TC7) for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility a multicenter study, FertU. Steril., 63, 709, 1995. 

Chowdhury, S. M. and Hubbell, J. A., Adhesion prevention with ancrod released via a tissue-adherent hydrogel, J. Surg. Res., 61, 58,19%. 

Shalaby, S. W., NIH SBIR Grant No. 1 R43 GM63291-01, Gel-forming Systems for Adhesion Prevention, Final Report, 2002. 

Connors R C, Muir J J, Liu Y, Reiss G R, Kouretas P C, Whitten M G, Sorenson T K, Prestwich G D and Bull D A (2007), Postoperative pericardial adhesion prevention using carbylan-sx in a rabbit model , J Surg Res, 140, 237-42. 

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