Tissue adhesion prevention

Matsuda, T., Miwa, H., Moghaddam, M.)., and lida, F. (1993) Newly designed tissue adhesion prevention technology based on photocurable mucopolysaccharides In vivo evaluation. ASAIO Trans., 39, M327-M331. 

Post-operation tissue adhesion can occasionally cause serious complications. Materials for tissue adhesion prevention should be flexible and tough enough to provide a tight cover over the traumatized soft tissue. In addition, they should be... 

Nanomaterials science for interfacing with living tissues, for delivery of pharmaceuticals, tissue-engineering scaffolds, wound repair, adhesion prevention, and other biological agents and medical devices. 

Chowdhury, S. M. and Hubbell, J. A., Adhesion prevention with ancrod released via a tissue-adherent hydrogel, J. Surg. Res., 61, 58,19%. 

Tissue sections should be collected on poly-L-lysine (PLL) coated slides to prevent loss of material during the many steps of the hybridization procedure. The best tissue adhesion is obtained if the sections are left to dry for at least 4 h (or overnight) at 37 C before use or storage. 

Tissue Plasminogen Activator Adhesion prevention Wiseman el al, 1992... 

The wide range of practical medical applications of hyaluronan continues to be based upon its anti-inflammatory, disinfectant and wound healing effects. HA promotes epithelial regeneration prevents the formation of granulation tissue, adhesions and scars reduces swelling and itching normalizes blood circulation promotes scarring of venous ulcers and protects internal eye tissue [24]. 

When the horn of the uterus, body tendons, and intestinal are damaged, tissue adhesion often results. (See Table 3 for data on adhesion preventative membranes for several types of surgery.) In order to prevent this phenomenon, a viscous polymer aqueous solution, sihcone sheet, poly(4-fluoroethylene) sheet, amnion, regenerated collagen membrane, and an oxidized cellulose cloth have all been used. However, none of these methods provide satisfactory results. Unsatisfactory results probably occur as a result of blood clot formation, tissue damage Ifom remaining materials, premature absorption by the body, lack of flexibility, and... 

Anti-adhesive materials have been developed to prevent tissue adhesion by providing a physical barrier between an injured site and the adjacent tissues. Although several non-absorbable synthetic materials such as silicone and PTFE have been shown to be effective, bioabsorbable materials are preferred because of the lack of necessity of secondary surgery to remove non-absorbable materials and the lack of need to consider long-term biocompatibihty such as encapsulation of the material, which will also evoke tissue adhesion. Moreover, non-absorbable synthetic materials have been shown to form adhesions on long-term application [99]. A wide variety of substances and materials have been used over the years. Commercially available anti-adhesive products are summarized in Table 8.7. 

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